Immunotherapy With CEA(6D) VRP Vaccine (AVX701) in Patients With Stage III

Clinical Trial Summary

This is a pilot study to evaluate the safety of a vaccine that consists of an alphavirus replicon (VRP) encoding the protein (CEA) that has been found to be associated with cancers such as colon cancer in patients that have stage III colon cancer. We will also evaluate the patient immune response to the vaccine.

See also
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Completed	`NCT00003835` - Combination Chemotherapy in Treating Patients With Stage III Colon Cancer	Phase 3
Recruiting	`NCT05062889` - Exploiting Circulating Tumour DNA to Intensify the Postoperative Treatment Resected Colon Cancer Patients	Phase 2
Recruiting	`NCT04416490` - Oxaliplatin Adjuvant Chemotherapy After Curative Resection of Primary Colon Cancer
Active, not recruiting	`NCT02836977` - Maintenance Tegafur-uracil Versus Observation Following Adjuvant Oxaliplatin-based Regimen in Patients With Stage III Colon Cancer After Radical Resection	N/A
Completed	`NCT00005818` - SU5416 and Irinotecan in Treating Patients With Advanced Colorectal Cancer	Phase 1/Phase 2
Completed	`NCT00019006` - Vaccine Therapy in Treating Patients With Colon, Pancreatic, or Lung Cancer	Phase 1
Recruiting	`NCT05174169` - Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease	Phase 2/Phase 3
Not yet recruiting	`NCT06287814` - French Assessment of MRD by Liquid Biopsies in Stage III CRC Patients (FRENCH.MRD.CRC)
Terminated	`NCT01606124` - Polyphenon E in Treating Patients With High-Risk of Colorectal Cancer	Phase 2

NCT number	NCT01890213
Study type	Interventional
Source	Duke University
Contact
Status	Completed
Phase	Phase 1
Start date	November 2013
Completion date	July 2019

Immunotherapy With CEA(6D) VRP Vaccine (AVX701) in Patients With Stage III Colorectal Cancer

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms