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Comparison of High-Dose Rate Brachytherapy and Stereotactic Ablative Radiotherapy as Monotherapy for the Treatment of Localized Prostate Cancer

Stage II Prostate Cancer AJCC v8 Clinical Trial

Official title:
A Pilot Study Comparing High-Dose Rate Brachytherapy and Stereotactic Ablative Radiotherapy as Monotherapy in Localized Prostate Cancer

Clinical Trial Summary

This phase II trial compares high-dose rate brachytherapy and stereotactic ablative radiotherapy as monotherapy in treating patients with prostate cancer that has not spread to other parts of the body (localized). High-dose rate brachytherapy delivers radiation directly into the prostate within a few minutes by a single radioactive seed through temporarily placed plastic catheters inside the prostate gland. Stereotactic ablative radiotherapy is an external beam radiation method that delivers large doses of radiation to the cancer in a short period of time, usually 5 treatments. This trial aims to find which of these two approaches is better in terms of patient-reported quality of life.

Clinical Trial Description

PRIMARY OBJECTIVE: I. To assess feasibility of a pilot non-randomized trial evaluating stereotactic ablative radiotherapy (SABR) and high-dose rate brachytherapy for localized prostate cancer. OUTLINE: Patients elect to participate in arms 1 or 2. ARM I: Patients undergo high-dose rate brachytherapy (HDR). ARM II: Patients undergo SABR every other day for 5 treatments. After completion of study treatment, patients are followed up periodically. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04253483
Study type Interventional
Source Rutgers, The State University of New Jersey
Contact
Status Recruiting
Phase Phase 2
Start date July 17, 2019
Completion date September 1, 2024
View Details
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