Stage I Prostate Cancer Clinical Trial
Official title:
Cell Kinetic Study of Bromodeoxyuridine (BrdU) in Prostate Cancer
Phase II trial to study the effectiveness of broxuridine in treating patients who are undergoing surgery for stage I or stage II prostate cancer. Broxuridine may help doctors determine the rate of growth of prostate tumors and help them plan effective treatment
OBJECTIVES:
I. Measure the potential doubling times of multifocal adenocarcinomas of the prostate using
broxuridine.
II. Determine whether the doubling times of multifocal carcinomas occurring within a single
prostate are consistent with a model in which low-volume carcinomas have slow doubling times
and high-volume carcinomas have fast doubling times.
OUTLINE:
Patients receive broxuridine IV over 30 minutes on day -1. Approximately 12-96 hours later,
patients undergo surgery to remove the prostate. Tumor tissue is examined by immunostaining
for the presence of broxuridine to determine doubling times of the tumor.
;
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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