Optimal Dose of Acetylsalicylic Acid After Coronary Artery Bypass Grafting

Status Completed

Clinical Trial Summary

This is a single-center, open-label, randomized controlled trial. Patients with stable angina pectoris without use of dual antiplatelet therapy or anticoagulation therapy scheduled for coronary artery bypass grafting (CABG) at Karolinska University Hospital in Stockholm, Sweden will be eligible.

This study investigates in patients having undergone CABG whether increasing the dose or the frequency of acetylsalicylic acid (ASA) treatment improves the efficacy of ASA regarding platelet inhibition compared to the standard dosing for cardiovascular prevention (75 mg once daily) in the first three months after surgery. Patients will be randomly assigned to postoperative ASA dose 75mg once daily, 75mg twice daily or 160 mg once daily. The study dose ASA will be started at hospital discharge and continued of three months. Blood samples for serum thromboxane B2 (TxB2) and other analyses will be taken before surgery, before discharge, and after one and three months. All available data will be collected prospectively. Informed consent will be obtained from patients meeting the inclusion criteria before the initiation of any study-specific procedures.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02482857
Study type	Interventional
Source	Karolinska University Hospital
Contact
Status	Completed
Phase	Phase 2/Phase 3
Start date	December 2011
Completion date	July 2015

View Details

See also
Status	Clinical Trial	Phase
Active, not recruiting	`NCT02892903` - In the Management of Coronary Artery Disease, Does Routine Pressure Wire Assessment at the Time of Coronary Angiography Affect Management Strategy, Hospital Costs and Outcomes?	N/A
Not yet recruiting	`NCT02871622` - BMX Alpha Registry: a Post-market Registry of the BioMatrix Alpha TM	N/A
Completed	`NCT02252406` - Impact of Ranolazine in Blood Markers in Women With Angina and Metabolic Syndrome	Phase 4
Not yet recruiting	`NCT02550301` - Does Mean Platelet Volume Change With Clopidogrel	N/A
Active, not recruiting	`NCT02244853` - Heart Rate and Cardiovascular Diseases Prognosis in People With Stable Coronary Artery Disease	N/A
Not yet recruiting	`NCT01162902` - Comparison of Vascular Remodeling Between Different Antianginal Medication Evaluated by Noninvasive ECG-gated Fundus Photographic Evaluation	Phase 4
Completed	`NCT01826552` - Comparison of the Angiographic Result of the Orsiro Hybrid Stent With Resolute Integrity Stent	Phase 4
Completed	`NCT02126150` - United Coronary Biobanks	N/A
Completed	`NCT01328470` - Effect of Platelet Inhibition According to Clopidogrel Dose in Patients With Chronic Kidney Disease	Phase 4
Completed	`NCT01769079` - Clinical Impact of the Withdrawal of Nitrate in Patients With Stable Angina	Phase 4
Unknown status	`NCT00751491` - Clopidogrel Versus Adenosin in Non Urgent Percutaneous Coronary Intervention (PCI)	Phase 3
Completed	`NCT00263263` - RRISC Study: Reduction of Restenosis In Saphenous Vein Grafts With Cypher Sirolimus-Eluting Stent.	Phase 2
Recruiting	`NCT04929496` - Physiology as Guidance to Evaluate the Direct Impact of Coronary Lesion Treatment: The PREDICT Study	N/A
Completed	`NCT03103620` - Safety and Effectiveness Evaluation of COBRA PzF Coronary Stent System: A Post Marketing Observational Registry
Recruiting	`NCT05459051` - Finding the Invasive Haemodynamic Threshold for Symptom Relief in Stable Angina
Not yet recruiting	`NCT04403048` - Drug Coated Balloon for Side Branch Treatment vs. Conventional Approach in True Bifurcation Coronary Disease: PRO-DAVID	N/A
Completed	`NCT01974492` - Comparison of Saphenous Vein Graft Harvested From Upper Versus Lower Leg in Coronary Artery Bypass Grafting	N/A
Completed	`NCT02120859` - Optical Coherence Tomography to Investigate FFR-Guided DEB-only Elective Coronary Angioplasty	Phase 4
Completed	`NCT01990924` - Low Rate Fluoroscopy to Reduce Radiation Dose During Coronary Angiography and Intervention	N/A
Terminated	`NCT01394848` - Safety and Efficacy Study of Endothelial Progenitor Cell Capture Stent With 1 Months Dual Antiplatelet Therapy	Phase 4