International Randomized Comparison Between DES Limus Carbostent and Taxus DES in the Treatment of De-novo Coronary Lesions

Stable Angina Clinical Trial

— NEXT  

Official title:

International Randomized Comparison Between DES Limus Carbostent and Taxus Drug Eluting Stents in the Treatment of De-novo Coronary Lesions. The NEXT Study.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01373502
• Other study ID #: C20902
• Status: Completed
• Phase: N/A
• Start date: October 2009
• Est. completion date: October 2015

Study information

• Verified date: April 2018
• Source: CID - Carbostent & Implantable Devices
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to demonstrate non-inferiority in terms of safety and efficacy of DES Limus Carbostent compared to the Taxus Liberté in treating de-novo atherosclerotic lesions in native coronary arteries.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 323
• Est. completion date: October 2015
• Est. primary completion date: April 2011
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Age = 18 years

• Patient is eligible for percutaneous coronary intervention (PCI) and for surgical revascularization (CABG)

• Patient has been informed of the nature of the study and agrees to its provisions and has provided written informed consent as approved by the Ethical Committee of the respective clinical site

• Patients with clinical evidence of ischemic heart disease and/or a positive functional study(e.g. stress test); documented stable (CCS I-IV) or unstable angina pectoris (Braunwald class I-II B and C) or documented silent ischemia

• LVEF>30%

• Requires treatment of a single de novo lesion in a native coronary artery in one or two different major epicardial vessels (LAD, LCX or RCA). The second lesion must fit with inclusion/exclusion criteria and must be treated with the same study stent as the first lesion

• Target lesion should be located in a target vessel with a diameter ranging from 3.0 to 3.75 mm

• Target lesion diameter stenosis > 50% and < 100% by visual estimate, with a TIMI flow of = 1

• The target lesion must be appropriately covered (margin of 2.5 mm on both sides of the stent) by one study stent (DES Limus Carbostent or Taxus Liberté, according to the randomization arm). Any occurred dissection of the target vessel must be treated with an additional stent (DES Limus Carbostent or Taxus Liberté, according to the randomization arm)

• Patient that underwent BMS implantation more than 6 months before the enrolment or DES implantation more than 1 year before the enrolment in an other vessel.

Exclusion Criteria:

• Female with childbearing potential or lactating

• Known sensitivity to sirolimus, paclitaxel, the polymeric matrix, stainless steel or cobalt chromium

• Acute Q-wave or non Q-wave myocardial infarction within 72 hours, or presents with CK elevation greater than 2 times upper limit normal associated with elevated CK-MB

• Cardiogenic shock

• Cerebrovascular accident within the past 6 months

• Acute or chronic renal dysfunction (defined as creatinine greater than 2.0 mg/dl)

• Contraindication to aspirin or clopidogrel

• Thrombocytopenia (platelet count less than 100,000/mm³)

• Active gastrointestinal bleeding within the past 3 months

• Known bleeding or hypercoagulable disorder

• Prior anaphylactic reaction to contrast agents or contrast sensitivity that cannot be controlled with pre-medication

• Currently under immunosuppressant therapy

• Currently, or has been treated with either Rapamune or paclitaxel within 12 months of the procedure

• Active infection

• Co-morbidities that could interfere with completion of study procedures, or life expectancy less than 1 year;

• Participating in another investigational drug or device trial that has not completed the primary endpoint or would interfere with the endpoints of this study

• Patient underwent coronary revascularization to any vessel within 30 days

• Patient underwent target vessel revascularization within 6 months

• Target vessel has had prior stent placement

• Presence of two lesions located in the same vascular territory (same major epicardial vessel)

• Prior coronary brachytherapy

• There is a planned target lesion treatment with any technique other than the pre-dilatation balloon angioplasty

• Treatment of more than two lesions is required at the time of enrolment, or is planned within 30 days following enrolment

• Any planned surgery within 6 months after index procedure

• Left main disease greater than 50% diameter stenosis

• Significant (>50%) stenosis proximal or distal to the target lesion that might require revascularization or impede run off

• Heavily calcified vessel and/or lesion which cannot be successfully predilated

• Target lesion is located or supplied by an arterial or venous bypass graft

• Ostial target lesion or lesion located within 2 mm of a bifurcation

• Target lesion involves a side branch >2.0 mm in diameter with an ostial disease

• Target lesion has TIMI 0 flow

• Target vessel with angiographically visible thrombus or unsuitable for proper stent delivery and deployment.

Related Conditions & MeSH terms

• Angina Pectoris
• Angina, Stable
• Angina, Unstable
• Documented Silent Ischemia
• Ischemia
• Stable Angina
• Unstable Angina

Intervention

Device:
• DES Limus Carbostent
DES Limus Carbostent Carbofilm Coated Coronary Stent
• Taxus Liberté Stent
Taxus Liberté Coronary Stent

Locations

Country	Name	City	State
Belgium	Academisch Ziekenhuis Middelheim	Antwerpen
Belgium	Ziekenhuis Oost Limburg	Genk
France	Clinique les Franciscaines	Nimes
France	Institut Mutualiste Montsouris	Paris
France	Clinique Saint-Hilaire	Rouen
France	Hôpital de Rangueil	Toulouse Cedex 4
Germany	Medizinisches Versorgungszentrum	Hamburg
Germany	Krankenhaus der Barmherzigen Brüder	Trier
Italy	Azienda Ospedaliera Careggi	Firenze
Italy	Istituto di Fisiologia Clinica del CNR	Massa
Italy	Ospedale S. Camillo	Roma

Sponsors (1)

Lead Sponsor	Collaborator
CID - Carbostent & Implantable Devices

Countries where clinical trial is conducted

Belgium,  France,  Germany,  Italy, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	angiographic efficacy measurement (mm)	in-stent Late Lumen Loss (LLL) measurement by angiography	180 days
Secondary	QCA measurements in-stent and in-segment		180 days
Secondary	IVUS measurements		180 days
Secondary	Incidence of cardiac death (%)		30 days, 180 days, 1, 2 , 3, 4 and 5 years
Secondary	Stent Thrombosis		acute, 30 days, 180 days, 1 year, > 1 year
Secondary	Acute success (Device and Procedural success)		acute
Secondary	Incidence of Myocardial Infarction (%)		30 days, 180 days, 1, 2, 3, 4, 5 years
Secondary	Incidence of clinically indicated TLR (%)		30 days, 180 days, 1, 2, 3, 4, 5 years
Secondary	Incidence of all deaths (%)		30 days, 180 days, 1, 2, 3, 4, 5 years
Secondary	Incidence of all repeat revascularization (%)		30 days, 180 days, 1, 2, 3, 4, 5 years

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