Squamous Cell Carcinoma Clinical Trial
Official title:
Neoadjuvant Chemotherapy Followed by Preoperative Chemoradiation in Resectable Squamous-cell Esophageal Cancer: Single Arm Phase II Study
This study is conducted to evaluate efficacy and safety of neoadjuvant chemotherapy followed by preoperative chemoradiotherapy in patients with resectable esophageal squamous cell carcinoma
This study is conducted to evaluate efficacy and safety of neoadjuvant chemotherapy followed
by preoperative chemoradiotherapy in patients with resectable esophageal squamous cell
carcinoma.
Patients with resectable esophageal squamous cell carcinoma receive 2 cycles of neoadjuvant
chemotherapy (paclitaxel 175 mg/м2 iv day 1, cisplatin 75 mg/м2 iv day 1, fluorouracil 750
mg/m2/day continuous infusion, day 1-4 every 3 weeks). Patients who do not progress with
distant metastases start preoperative chemoradiotherapy (paclitaxel 50 mg/m2 + cisplatin 20
mg/m2 weekly + radiotherapy 44 Gy for 4 weeks).
4-6 weeks after completion of chemoradiation patients undergo Ivor Lewis esophagogastrectomy
irrespectively of objective response.
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