Squamous Cell Carcinoma Clinical Trial
Primary cutaneous squamous cell carcinomas (SCCs) are epithelial carcinomas with a high
frequency of EGF-R expression. EGFR is an important regulator of tumour progression and
proliferation in several types of cancer. Mechanism of action of Lapatinib in the EGFR
and/or HER2 expressing oesophageal squamous cell carcinoma (ESCC) cells is attributed to
inhibition of cell proliferation and induction of apoptosis. Based on the data from
oesophageal SCCs the investigators hypothesise that EGFR signalling pathway and its
interactions play an important role in the SCC pathogenesis and represent a good therapeutic
target from these tumours.
Primary Objectives:
To evaluate the tumour response macroscopically in patients with primary cutaneous SCC
lesions and in concomitant SCC in situ (AK).
Secondary Objectives:
- To evaluate tolerability of a single dose regimen of systemic lapatinib therapy in
patients with SCC as measured by time to first AE or SAE within the study period.
- To investigate the molecular tumour response of squamous cell carcinoma lesions in
patients under lapatinib treatment using a set of variables.
- Trial with medicinal product
n/a
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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