Sports Nutritional Sciences Clinical Trial
Official title:
Opioid System Cerebral Activity in Endurance Sportswomen - Addiction or Denutrition ? [11C]Diprenorphine PET Study
Verified date | October 2017 |
Source | Centre Hospitalier Universitaire de Saint Etienne |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Abnormal opioid system have been identified in addictive behavior and activity of the opioid
system has also shown a strong link with the nutritional balance. A significant increase in
endorphin levels was noticed after exercise, proportional to the duration and intensity of
this activity. One brain imaging study showed an increase in opioid activity in athletes
after endurance training. However , a decrease in opioid tone related to receptor
desensitization in the brain has been raised in the sport and it is possible to feel like ,
the subject must perform physical exercise more frequently . Consequently, in order to deepen
the hypothesis of addiction in high-level sport , the brain opioid activity should be
assessed pre- training compared to a group of sedentary control subjects .
Preliminary results of a previous study the investigators are conducting on anorexia nervosa
(AN ) show abnormalities that appear to be involved in self addiction anorexia nervosa and
the regulation of gonadal function. However, the relation of cause and effect between these
anomalies and undernutrition remains to be determined . Given the addictive component in the
endurance sport and the variability of the nutritional status of its practitioners ,
evaluation of brain activity in these subjects could provide additional answers.
Status | Completed |
Enrollment | 35 |
Est. completion date | July 7, 2017 |
Est. primary completion date | July 6, 2017 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 18 Years to 35 Years |
Eligibility |
Inclusion Criteria: For High-level sportswomen : - 18-35-year-old - High-level sportswomen - BMI>19kg/m2 - Absence of eating disorders - In pre-competition period - Signature of written consent For controls : - 18-35-year-old - Sedentary normal weight women - BMI>19kg/m2 - Normal nutritional markers - Absence of eating disorders or other psychiatric or organic diseases Exclusion Criteria: - Oral contraception - Heart failure - Neuroleptics, antiparkinson drugs, alpha-methyl-dopa, beta blockers, inhibitors of monoamine oxidase-A or MOA-B, tricyclic antidepressants, selective serotonin reuptake inhibitor, thyme-regulators (lithium), anticonvulsant drugs, codeine, morphine, drugs containing tramadol, dopaminergic drugs |
Country | Name | City | State |
---|---|---|---|
France | Service d'Endocrinologie - CHU Saint-Etienne | Saint-Etienne |
Lead Sponsor | Collaborator |
---|---|
Centre Hospitalier Universitaire de Saint Etienne | Ministry of Health, France |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | [11C]diprenorphine binding potential | Value of [11C]diprenorphin binding potential in predifined brains regions. [11C]diprenorphin BP will be evaluated by brain positron emission tomography and MRI exam | 2 weeks | |
Secondary | correlation [11C]diprenorphine BP | Correlation between [11C]Diprenorphine binding potential and plasma endogenous opioid levels | 2 weeks | |
Secondary | correlation [11C]diprenorphine BP | Correlation between [11C]Diprenorphine binding potential and psychometric score evaluating addictive behavior, reward and positive reinforcement | 2 weeks | |
Secondary | correlation [11C]diprenorphine BP | Correlation between [11C]Diprenorphine binding potential and appetite regulating hormones | 2 weeks | |
Secondary | correlation [11C]diprenorphine BP | Correlation between [11C]Diprenorphine binding potential and LH response during GnRH test | 2 weeks |
Status | Clinical Trial | Phase | |
---|---|---|---|
Not yet recruiting |
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