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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT05350176
Other study ID # Lact.Bas
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date October 10, 2023
Est. completion date December 20, 2023

Study information

Verified date January 2024
Source University of the Basque Country (UPV/EHU)
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

This study will be performed with the aim to evaluate the effects of probiotic supplementation on sport performance and gut damage. Participants will be divided into two groups, placebo and experimental group. With the purpose to assess the effects of probiotics on the gut damage, a strenuous exercise session will be performed, and then blood samples will be taken to observe the variation of the selected intestinal damage marker. 24 hours after this strenuous session, performance tests will be performed. After the 4 weeks of supplementation, the same procedure will be followed to evaluate the effect of probiotics.


Description:

One week before the initiation of the study participants will be required to avoid consuming drugs, alcohol, cigarettes, probiotics, and any other food or liquid which could modify gut microbiota composition. For the baseline values, height, weight and sports performance test, of the participants will be collected. The same day, a strenuous exercise session will be performed in order to observe the variation of the intestinal damage marker (blood sample extraction just after finishing the strenous exercise session). 24 hours after that session sport performance tests will be conducted. Participants will then be randomly divided into two groups, one of which will take one probiotic capsule per day containing 10 billion colony-forming units (CFU) of Lactobacillus plantarum, and the other group will take one placebo capsule per day consisting of dextrose. The supplementation period will last 4 weeks. After the supplementation period, the same process will be followed, with the same strenuous exercise session and immediate blood sampling to determine the effects of probiotics on the intestinal damage caused by exercise. 24 hours later, performance tests will be conducted to assess the effects of probiotics on sport performance.


Recruitment information / eligibility

Status Completed
Enrollment 24
Est. completion date December 20, 2023
Est. primary completion date November 20, 2023
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Male
Age group 18 Years and older
Eligibility Inclusion Criteria: - Healthy - No injuries - 1 year of CrossFit practicing experience Exclusion Criteria: - Drug, alcohol, cigarettes, probiotic intake - Injuries

Study Design


Related Conditions & MeSH terms


Intervention

Dietary Supplement:
Probiotic
Probiotic capsules will be composed of 10 billion CFU of Lactobacillus plantarum.
Placebo
Capsules containing dextrose (1 capsule per day)

Locations

Country Name City State
Spain CrossFit Bikain Vitoria Alava

Sponsors (1)

Lead Sponsor Collaborator
University of the Basque Country (UPV/EHU)

Country where clinical trial is conducted

Spain, 

Outcome

Type Measure Description Time frame Safety issue
Primary Intestinal-fatty acid-binding protein Gut damage marker 0-10 minutes after strenuous exercise blood samples will be extracted
Primary Counter movement jump test Jumping test 24 hours after strenuous training session. First test to be performed
Primary Running Based Anaerobic Sprint Test Running test 24 hours after strenuous training session. Second test to be performed
Primary YO YO Intermittent Recovery Level test 1 aerobic test 24 hours after strenuous training session. Third test to be performed
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