Sporadic Migraine Clinical Trial
Official title:
Randomised Sham-controlled Trial of Anodal Transcranial Direct Current Stimulation (tDCS) for the Prevention of Episodic Migraine
Anodal tDCS increases the excitability of the cerebral cortex and its daily application during intercritical phase, may have a therapeutic effect in episodic migraine.
During the interictal phase, the cerebral cortex is characterised by hyperresponsiveness to
repeated sensory stimuli, manifested by a lack of habituation or adaptation of cortical
evoked responses. Such habituation deficit can be shown in the visual cortex by the study of
visual evoked potentials (VEP) and it is possibly explained by a reduction in the cortical
pre-activation level due to thalamo-cortical dysrhythmia. In healthy subjects and in
migraineurs between attacks, anodal tDCS increases VEP habituation and 1st block amplitude.
In a proof-of-concept trial, the investigators have shown in 10 episodic migraine without
aura patients that 2 weekly 15-minute sessions for 8 weeks of anodal tDCS over the visual
cortex significantly decreased attack frequency, migraine days, attack duration and acute
medication intake for more than 4 weeks after the last treatment session.
This randomized trial was designed to prove the preventive effect in episodic migraine of
anodal tDCS over the visual cortex compared to sham stimulation.
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