Spondyloarthropathy Clinical Trial
Official title:
A Prospective Study of the Use of the Madrid Ultrasound Scoring System in the Treatment of Anti-TNF Blocker to Peripheral Tendonitis in Patients With Spondyloarthritis
NCT number | NCT02960035 |
Other study ID # | [2015]2-158 |
Secondary ID | |
Status | Completed |
Phase | Phase 4 |
First received | |
Last updated | |
Start date | April 2014 |
Est. completion date | October 2018 |
Verified date | December 2019 |
Source | Sun Yat-sen University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
This is a randomized, double-blind, multicentral clinical trial to investigate the efficacy of Recombinant Human Tumor Necrosis Factor-α Receptor Ⅱ IgG Fc fusion protein injection (Yisaipu®) in the treatment of peripheral enthesitis in active axial spondyloarthritis(SpA) patients.
Status | Completed |
Enrollment | 96 |
Est. completion date | October 2018 |
Est. primary completion date | September 2016 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 65 Years |
Eligibility |
Inclusion Criteria: - Fulfill the 2009 ASAS criteria for axial spondyloarthritis(SpA), and without bilateral more than grave 2 or unilateral more than grave 3 sacroilitis on X ray plan - Active disease phase of SpA, defined as BASDAI=4 or ASDAS=2.1 - Inadequate response to NSAID=4 week - Application of NSAID with stable dose for no less than 2 weeks - Stable dose of prenisone for at least four weeks at =10mg per day if used at screening, or stop use for at least 4 weeks - Stable dose of any DMARD for at least four weeks if used at screening, or stop use for at least 4 weeks - Stop and receiving washing out for at least 4 week if receiving Chinese traditional drug for AS, physical treatment, vaccication or IVIG - The lab exam should achieve the criteria as below: - Hb = 85g/L - 3.5×109/L = WBC count = 10×109/L - PLT = lower limit of normal range - ALT = 2 fold of upper limit of normal range - serum creatine = upper limit of normal range - Negative pregnacy test for female patients. And promise to carry out contraception during the trial and 6 weeks after the trial is ended - Sign the informed consent Exclusion Criteria: - Previous application of any biologic agents - Allergic to any element of Yisaipu® - Intolerance to NASID - History of active tubercolosis, or radiographic evidence of present or previous history of pulmonary tubercolosis, or close contact with patients with tubercolosis, or with high risk of infection of tubercolosis such as immune suppression status, or strong positive of PPD skin test with diameter =10mm - Presence of acute infection or acute onset of chronic infection at screen - Invasive fungal infection or conditional infection within 6 months prior to screen - Present or history of serious liver disease - History of infection on artifitial joints - Organ transplantation surgery within 6 months prior to screen - Presence of other autoimmune diseases, including IBD, psoriasis, uveitis, SLE, multiple sclerosis, etc - History of congestive heart failure - History of malignancies within 5 years prior to screen, excluding complete resection of squamous cell carcinoma, or basal cell carcinoma or cervical carcinoma in situ - AIDS or HIV infection - History of lymphoma or lymphoproliferative disorders - Presence of serious disorder of important organs or system - Presence of factors which may influence the compliance |
Country | Name | City | State |
---|---|---|---|
China | Department of Rheumatology, the Third Affiliated Hospital of Sun Yat-sen University | Guangzhou | Guangdong |
Lead Sponsor | Collaborator |
---|---|
Sun Yat-sen University |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | The change of Mardird sonographic enthesis index (MASEI) at 24 weeks | The change of Mardird sonographic enthesis index (MASEI) from week 0 to week24 | 24 weeks |
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