Spondyloarthritis Clinical Trial
Official title:
Comparison of Sodium Fluoride Positron Emission Tomography and Magnetic Resonance Imaging of Spine and Sacroiliac Joints for Detection of Inflammatory Lesions in Patients Affected by Spondyloarthritis
The purpose is to compare detection of axial inflammatory lesions in patients affected by
spondyloarthritis (SpA) with sodium fluoride positron emission tomography (PET) and magnetic
resonance imaging (MRI), the reference technique.
It would be interesting to show the superiority of sodium fluoride PET on MRI for diagnosis
of inflammatory lesions. It could be used for diagnostic care but also therapeutic care of
patients with early forms of spondyloarthritis.
Secondary purposes are:
- To evaluate performances of sodium fluoride PET in detection of SpA peripheral damage
(except spine and sacroiliac joints)
- To evaluate bone inflammation (axial and peripheral) with sodium fluoride PET and
compare these data to clinic-biologic parameters used in clinical practice (BASDAI,
BASFI, BASMI, sedimentation rate, C-reactive protein (CRP)) and to structural
evaluation (sacroiliac New York, mSASSS and BASRI scoring methods)
- To study correlation of axial and peripheral bone inflammation (spine and sacroiliac
joints) evaluated with sodium fluoride PET with biologic markers of inflammation and
bone remodeling (MMP-3; DKK-1, IL-6, IL-17, TNF-α).
Known biologic markers of inflammation in SpA are correlated to activity obtained with MRI.
It is interesting to compare to activity obtained with PET. Moreover, it has been recently
showed the disassociation of inflammation and structural progression (anti-TNF treatments do
not prevent structural progression) that is associated to markers of bone remodeling whose
activity is influenced by an activation/inhibition system of biologic markers of
inflammation.
n/a
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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