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Evolution of Intestinal Microbiota in Patients With Juvenile Spondylarthropathy According to Typology of Treatment — MESAJ  

Spondylarthropathies Clinical Trial

Official title:
Descriptive Study on the Evolution of Intestinal Microbiota Profiles in Patients With Juvenile Spondylarthropathy According to the Typology of Treatment and Response to it: A Descriptive, Prospective Pilot Study

Clinical Trial Summary

Idiopathic juvenile arthritis includes 20% of patients with arthritis with enthesitis or juvenile spondyloarthropathy. This is treated with anti-inflammatory drugs and then followed by biotherapy with DMARDs (Drugs Modifying the Activity of Rheumatic Disease) if the former are insufficient. Methotrexate (MTX) may also be used before these biotherapies. Recently, in adults, a particular profile of intestinal microbiota has been shown to alter the availability of MTX making it in efficient. Knowing that pediatric patients with juvenile spondyloarthropathy have an imbalance of their intestinal flora (dysbiosis) the investigators wanted to explore whether DMARDs could have a similar impact on the microbiota of these young patients and alter the response to treatment.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04540432
Study type Interventional
Source Centre Hospitalier Universitaire de Nimes
Contact Tu-Anh TRAN, Professor
Phone +33 4 66 32 86
Email tu.anh.tran@chu-nimes.fr
Status Recruiting
Phase N/A
Start date September 22, 2021
Completion date June 28, 2027
View Details
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