Patient- and Task-specific Radiation Dose Optimization for Pediatric Abdominopelvic CT Applications

Split Dose CT Clinical Trial

Official title:

Patient- and Task-specific Radiation Dose Optimization for Pediatric Abdominopelvic CT Applications

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT03429712
• Other study ID #: Pro00077173
• Status: Terminated
• Phase: N/A
• Start date: September 15, 2018
• Est. completion date: April 12, 2019

Study information

• Verified date: November 2019
• Source: Duke University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Radiation dose reduction has been a primary driver of technology development in multi-detector computed tomography (MDCT). The optimization of radiation dose for patient and task specific computed tomography (CT) applications continues to be an ongoing challenge, especially in pediatric patients where the desire to reduce radiation dose to lowest possible levels leads to both positive and negative effects. A novel research tool on the Siemens dual source (Flash® and Force ®) CT scanners allows one to assess multiple tube current levels from a single CT acquisition without incurring additional dose to the patient. Tube current is a primary contributor to radiation dose and image noise, which are inversely related. This is achieved by independently adjusting the current of each tube, while maintaining same kV in each x-ray tube. Moreover, Duke's medical physics team has developed a method based on mathematical expressions that allows the creation of incremental dose levels from the acquired image data sets. This innovative and powerful tool can be used to compare diagnostic accuracy, detectability, and many more relevant clinical features amongst multiple tube current levels with the attainment of a single CT acquisition.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 19
• Est. completion date: April 12, 2019
• Est. primary completion date: April 12, 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: N/A to 18 Years

Eligibility

Inclusion Criteria:

-

Exclusion Criteria:

• Pregnant

Related Conditions & MeSH terms

• Split Dose CT

Intervention

Device:
• Dual-source multi-detector computed tomography (DSSE)
Dose split technique in a cohort of pediatric patients to determine, without increase in patient radiation dose, the optimal patient-specific and task-specific radiation dose levels for pediatric cardiothoracic and abdominal CT applications.

Locations

Country	Name	City	State
United States	Duke University Medical Center	Durham	North Carolina

Sponsors (1)

Lead Sponsor	Collaborator
Duke University

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Image Noise		Up to 5 minutes