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Spinocerebellar Degenerations clinical trials

View clinical trials related to Spinocerebellar Degenerations.

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NCT ID: NCT05951010 Completed - Clinical trials for Spinocerebellar Ataxias

Cerebellar Transcranial Direct Current Stimulation in Spinocerebellar Ataxia 38

Start date: November 1, 2022
Phase: N/A
Study type: Interventional

Spinocerebellar ataxia 38 (SCA 38) is a very rare autosomal dominant inherited disorder caused by a mutation in ELOV5 gene, specifically expressed in cerebellar Purkinje cells, encoding an enzyme involved in the synthesis of fatty acids. The present study aimed to assess the effect of cerebellar anodal transcranial direct current stimulation (tDCS) administered employing deltoid (CD-tDCS) and spinal (CS-tDCS) cathodal montage. Clinical evaluation was performed at baseline (T0), after 15 sessions of tDCS (T1) and after one month of follow-up (T2).

NCT ID: NCT05621200 Completed - Clinical trials for Multiple System Atrophy

Transcranial Alternating Current Stimulation (tACS) in Patients With Ataxia

SCAtACS
Start date: January 28, 2021
Phase: N/A
Study type: Interventional

The aim of the study is to evaluate the effects on motor and cognitive performance of transcranial alternating current stimulation (tACS) compared to transcranial direct current stimulation (tDCS) and placebo stimulation (sham) in patients with neurodegenerative ataxia to identify a possible rehabilitation protocol.

NCT ID: NCT05502432 Completed - Clinical trials for Spinocerebellar Ataxia Type 3

Repetitive Transcranial Magnetic Stimulation in SCA3 Patients

Start date: December 17, 2018
Phase: N/A
Study type: Interventional

Machado-Joseph Disease (MJD) or spinocerebellar ataxia type 3 (SCA3) is the most common spinocerebellar ataxia worldwide.Repetitive transcranial magnetic stimulation (rTMS) is a form of brain stimulation therapy used to treat depression and cerebellar ataxias. In this randomized, double-blind, sham-controlled study, the investigators will evaluate whether a 15 day treatment with 1 Hz of repetitive transcranial magnetic stimulation (rTMS) can improve symptoms (motor symptoms and non-motor symptoms) in patients with MJD.

NCT ID: NCT05436262 Completed - Cerebellar Ataxia Clinical Trials

Using Real-time fMRI Neurofeedback and Motor Imagery to Enhance Motor Timing and Precision in Cerebellar Ataxia

Start date: March 14, 2023
Phase: N/A
Study type: Interventional

The aim of the research is to improve motor function in people with cerebellar ataxia by using neuroimaging methods and mental imagery to "exercise" motor networks in the brain. The relevance of this research to public health is that results have the potential to reduce motor deficits associated with cerebellar atrophy, thereby enhancing the quality of life and promoting independence.

NCT ID: NCT05038306 Completed - Clinical trials for Medicine, Chinese Traditional

Chinese Medicine WT for Spinocerebellar Ataxia Type 3

Start date: May 31, 2021
Phase: Phase 2
Study type: Interventional

Spinocerebellar ataxia type 3 (SCA3) is one of autosomal dominant hereditary ataxias. Standing imbalance, unsteady gait, dysmetria, fatigue, and depression would occur gradually. There are no effective treatment or palliative methods for patients in the present days. However, low-dose growth hormone, or its downstream product, insulin-like growth factor I (IGF-1), may deter the progress of SCA3 in transgenic mice. The main bioactive constituent among the Chinese medicine WT possesses neuroprotective function against glutamate-induced toxicity, which is one major pathology of SCA3. It promotes neurogenesis, and increases the protein expression of IGF-1 in ischemic brains of rats. Thus, we designed a randomized, double-blind trial for patients with SCA3, if WT is a possible neuroprotective medicine. All the subjects will be recruited from Changhua Christian Hospital. Diagnosis is confirmed by gene test and magnetic resonance image by a neurologist. They will be assigned in random and double blind, prescribed with 3 grams concentrated powder of WT or placebo, twice a day, for 12 weeks. After the washout period of 4 weeks, there will be a crossover of placebo or WT for another 12 weeks. After that, another 4-week rest will be followed by the end of trial. Check items in five check points include: 1. Blood examination (serum IGF-1, Neurofilament light chain, mitochondria copy number, 8_OHdG, delta-Ct), 2.Neurological exam (Scale for the Assessment and Rating of Ataxia), 3. Questionnaires (Modified Fatigue Impact Scale, Epworth Sleepiness Scale), 4. Handgrip strength test (which is correlated to IGF-1 value in elderly), and 5. serum metabolites, . All the data will be disclosed after the end of trial. Paired-T test or Wilcoxon Ranked Sign Test will be operated in SPSS.

NCT ID: NCT04837027 Completed - Clinical trials for Spinocerebellar Ataxias

Effect of Training on Brain Volume in Ataxia

Start date: September 1, 2021
Phase: N/A
Study type: Interventional

The primary aim is to show balance training improves DCD individual's ability to compensate for their activity limitations, but does not impact disease progression. The second aim is to demonstrate aerobic exercise improves balance and gait in DCD persons by affecting brain processes and slowing cerebellar atrophy.

NCT ID: NCT04750850 Completed - Cerebellar Ataxia Clinical Trials

Core Stability Exercises and Hereditary Ataxia

Core-ataxia
Start date: May 20, 2021
Phase: N/A
Study type: Interventional

The hereditary ataxias are a group of genetic disorders characterized by slowly progressive incoordination of gait and balance impairments in sitting and standing. Trunk local stability during gait is lower in patients with degenerative ataxia than that in healthy adult population. Given the fact that drug interventions are rare in degenerative diseases and limited to only specific type of diseases and symptoms, physiotherapy is a major cornerstone in current therapy of ataxic gait. Core stability exercises training could be included as an adjunct to conventional balance training in improving dynamic balance and gait. Due to the nature of the interventions, the study will have a single blind design.

NCT ID: NCT04740359 Completed - Clinical trials for Ataxia, Spinocerebellar

Functional Trunk Training in Ataxia Patients

Start date: February 12, 2021
Phase: N/A
Study type: Interventional

The study is to examine the effect of functional trunk training on trunk control and upper extremity functions in patients with autosomal recessive ataxia.

NCT ID: NCT04595578 Completed - Clinical trials for Spinocerebellar Ataxias

Cerebellar rTMS and Physical Therapy for Cerebellar Ataxia

Start date: September 1, 2017
Phase: N/A
Study type: Interventional

The present study investigated the efficacy and safety of combination treatment of repetitive transcranial magnetic stimulation (rTMS) and physical therapy (PT) in patients with cerebellar variant of multiple system atrophy (MSA-C) and spinocerebellar ataxia.

NCT ID: NCT04426149 Completed - Clinical trials for Spinocerebellar Ataxia 3

Clinical Effects of Oral Trehalose In Patients With Spinocerebellar Ataxia 3

Start date: March 7, 2018
Phase: N/A
Study type: Interventional

There are no clinically established treatments which have been proven to delay the disease progression in spinocerebellar ataxia (SCA) 3. Most available treatments are only for symptom alleviation, and thus the majority of patients will eventually progress to needing and wheel chair and eventually bedridden. As trehalose appear to be potentially promising treatment in SCA, the investigators aim to conduct this study using oral trehalose in our genetically confirmed SCA 3 patients.