Multiple System Atrophy Clinical Trial
Official title:
Rehabilitative Trial With Cerebello-Spinal tDCS for the Treatment of Neurodegenerative Ataxia
Neurodegenerative cerebellar ataxias represent a group of disabling disorders for which we currently lack effective therapies. Cerebellar transcranial direct current stimulation (tDCS) is a non-invasive technique, which has been demonstrated to modulate cerebellar excitability and improve symptoms in patients with cerebellar ataxias. In this randomized, double-blind, sham-controlled study, the investigators will evaluate whether a two-weeks' treatment with cerebellar anodal tDCS and spinal cathodal tDCS can improve symptoms in patients with neurodegenerative cerebellar ataxia and can modulate cerebello-motor connectivity, at short and long term.
Neurodegenerative cerebellar ataxias represent a heterogeneous group of disabling disorders
in which progressive ataxia of gait, limb dysmetria, oculomotor deficits, dysarthria and
kinetic tremor are the prominent clinical manifestations. Both the hereditary and sporadic
forms usually present in young adulthood, and are characterized by atrophy of cerebellar or
brainstem structures. Currently, cerebellar ataxia lack effective disease-modifying
therapies.
Cerebellar transcranial direct current stimulation (tDCS) is a non-invasive technique, which
has been demonstrated to modulate cerebellar excitability and improve symptoms in patients
with cerebellar ataxias. The present randomized, double-blind, sham-controlled study will
investigate whether a two-weeks' treatment with cerebellar anodal tDCS and spinal cathodal
tDCS can improve symptoms in patients with neurodegenerative cerebellar ataxia and can
modulate cerebello-motor connectivity, at short and long term.
Subjects will be randomized in two groups, one receiving a 10 day (5 days/week for 2 weeks)
treatment with anodal cerebellar and cathodal spinal tDCS and the other receiving sham
stimulation with identical parameters. After the intervention, patients will be reassessed
with a clinical and neurophysiological evaluation at 2 weeks, 1 months and 3 month after
treatment.
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