Spinal Muscular Atrophy Clinical Trial
Official title:
Spinal Muscular Atrophy and Cardiac Autonomic Function
Respiratory dysfunction is the major cause of morbidity and mortality in patients with
spinal muscular atrophy (SMA). Air stacking is a clearance airway technique frequently used
but its effects on cardiac autonomic function in patients with spinal muscle atrophy is not
clear.
Objective: To evaluate the acute effect of air stacking and posture on cardiac autonomic
function in patients with spinal muscular atrophy types II and III.
Methods: Patients with spinal muscle atrophy type II and III will be recruited.
Electrocardiogram signals will be recorded for analyses of heart rate variability during air
stacking in supine and sitting position.
Background: Respiratory dysfunction is the major cause of morbidity and mortality in
patients with spinal muscular atrophy. Air stacking is a clearance airway technique
frequently used but its effects on cardiac autonomic function in patients with spinal muscle
atrophy is not clear.
Objective: To evaluate the acute effect of air stacking and posture on cardiac autonomic
function in patients with spinal muscular atrophy types II and III.
Methods: Patients with spinal muscle atrophy type II and III will be recruited.
Electrocardiogram signals will be recorded for analyses of heart rate variability during air
stacking in supine and sitting position. Data will collected before, during and after air
stacking and will be compared using Anova Repeated Measures or Kruskal-Wallis Anova on
Ranks, followed by Tukey test. The relationship between heart rate variability indexes and
age will be evaluated by Pearson correlation. Significant level will be set at 5%.
;
Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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