Surgical Outcome of Dorsolumbar Intradural Extramedullary Spinal Cord Tumors

Spinal Cord Tumor Clinical Trial

Official title:

Surgical Outcome of Dorsolumbar Intradural Extramedullary Spinal Cord Tumors

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05678608
• Other study ID #: soh-med-22-12-02
• Status: Recruiting
• Phase: N/A
• Start date: December 13, 2022
• Est. completion date: May 2023

Study information

• Verified date: December 2022
• Source: Sohag University
• Contact: mohamed M kassem, demonstrator
• Phone: 010980-03153
• Email: mohamed011152[@]med.sohag.edu.eg
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Primary spinal cord tumors constitute 2-4% of all central nervous system neoplasms; they are classfied as extradural, intradural extramedullary (IDEM: 65%), and intramedullary The most commonly seen IDEM tumors are schwannomas, neurofibromas, and meningiomas. [1] The less frequently encountered IDEM tumors include ependymomas, lipomas, hemangiomas, metastatic deposits, paragangliomas, nerve sheath myxomas, and vascular tumors.[2] Spinal cord tumors can cause different signs and symptoms, especially as tumors grow. The tumors may affect spinal cord or the nerve roots, blood vessels or bones of spine. Signs and symptoms may include: Pain at the site of the tumor due to tumor growth Back pain, often radiating to other parts of body Feeling less sensitive to pain, heat and cold Loss of bowel or bladder function Difficulty walking, muscle weakness . MRI is the investigation of choice,however other investigation such CT or X ray are important to ensure stability of the vertebral column and the optimal management is gross total excision for symptomatic lesions.[3,4] Over the years, there has been no significant change in the clinical symptoms and pathology of IDEM tumors. However, there have been dramatic improvements in the diagnosis and treatment with the advances of radiological and surgical techniques. Despite advances in operative techniques and neuroimaging, the morbidity associated with the resection of IDEM tumors continues to be significant [5,6]. Here, we examined the surgical outcomes of 20 patients with IDEM spinal cord tumors operated in Neurosurgery department at Sohag university Hospital

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 20
• Est. completion date: May 2023
• Est. primary completion date: May 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• patients with intradural extramedullary lesion in dorsolumber region

Exclusion Criteria:

• previous history of spinal surgery
• unfit medical patients
• multiple level affection
• associated cervical lesion
• unstable segment

Related Conditions & MeSH terms

• Spinal Cord Neoplasms
• Spinal Cord Tumor

Intervention

Procedure:
• surgical excision
posterior midline approach and total excision for spinal cord tumors

Locations

Country	Name	City	State
Egypt	Sohag University Hospital	Sohag

Sponsors (1)

Lead Sponsor	Collaborator
Sohag University

Country where clinical trial is conducted

Egypt, 

References & Publications (3)

Abul-Kasim K, Thurnher MM, McKeever P, Sundgren PC. Intradural spinal tumors: current classification and MRI features. Neuroradiology. 2008 Apr;50(4):301-14. doi: 10.1007/s00234-007-0345-7. Epub 2007 Dec 15. — View Citation

Narayan S, Rege SV, Gupta R. Clinicopathological Study of Intradural Extramedullary Spinal Tumors and Its Correlation With Functional Outcome. Cureus. 2021 Jun 18;13(6):e15733. doi: 10.7759/cureus.15733. eCollection 2021 Jun. — View Citation

Song KW, Shin SI, Lee JY, Kim GL, Hyun YS, Park DY. Surgical results of intradural extramedullary tumors. Clin Orthop Surg. 2009 Jun;1(2):74-80. doi: 10.4055/cios.2009.1.2.74. Epub 2009 May 27. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	american spinal injury association scale	grading of impairment for motor and sensory functions grade A for complete sensory and motor loss grade E for normal motor and sensory	6 months
Primary	visual analogue pain scale	pain scale from zero to ten depend on severity of pain,	6 months