Autoimmunity And Immune Deficiency After Spinal Cord Injury: Association With Rehabilitation Outcomes

Spinal Cord Trauma Clinical Trial

Official title:
Maladaptive Systemic Immune Response After Spinal Cord Injury: Humoral Post-traumatic Autoimmunity Against Central and Peripheral Nervous System Antigens in Association With Neurogenous Immune Depression as a Confounder of Rehabilitation

Status Not yet recruiting

Clinical Trial Summary

The SCIentinel-prolong study systematically analyzes humoral autoantibody responses and thier interaction with post-spinal cord injury (SCI) immune-deficiency and infections as well as their association with the clinical course of rehabilitation. Therefore, molecular and immunological tests in blood and cerebrospinal fluid specimen are combined with clinical outcomes ranging from neurological function, neuropathic pain and spasticity to walking tests and measures of independence in daily living within the first year after SCI. Including a control group with participants suffering from vertebral fractures without SCI allows to differentiate between neurological and general injury and treatment effects.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04211636
Study type	Observational
Source	Charite University, Berlin, Germany
Contact	Marcel A Kopp, MD
Phone	+49 30 450560075
Email	marcel.kopp@charite.de
Status	Not yet recruiting
Phase
Start date	October 2023
Completion date	April 2026

View Details

See also
Status	Clinical Trial	Phase
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Terminated	`NCT03089749` - Characterization of Human Autoantibody Titers After Central Nervous System Insult
Completed	`NCT02302157` - Dose Escalation Study of AST-OPC1 in Spinal Cord Injury	Phase 1/Phase 2
Completed	`NCT01321333` - Study of Human Central Nervous System Stem Cells (HuCNS-SC) in Patients With Thoracic Spinal Cord Injury	Phase 1/Phase 2
Completed	`NCT02201173` - Health Outcomes After Locomotor Training in Spinal Cord Injury	N/A
Recruiting	`NCT04460872` - Locomotor Training With Testosterone to Promote Bone and Muscle Health After Spinal Cord Injury	Phase 2
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