Spinal Cord Injury Clinical Trial
Official title:
The Use of Non-invasive Multidetector Coronary Computed Tomography Imaging for the Assessment of Coronary Calcification in Persons With Spinal Cord Injury
Although conventional risk factors for coronary heart disease (CHD) have been identified and
routinely used to determine risk for CHD in the general population, a systematic approach to
determine population-specific risk for CHD has not been performed prospectively in those
with SCI. CHD is a leading cause of death in spinal cord injury, occurring at younger ages
than in the able-bodied population. Conventional risk factors for CHD are high serum
concentrations of low-density lipoprotein (LDL), low serum concentrations of high-density
lipoprotein (HDL), diabetes mellitus (DM), positive smoking history, and positive family
history of premature CHD.
Coronary calcification (CAC) is a commonly occurring phenomenon that does not necessarily
indicate significant obstructive disease. Studies have shown that a strong association
exists between coronary calcification and coronary heart disease. The purpose of this study
is to compare the CAC scores in persons with SCI with a historical control group of
able-bodied persons from a national data base who will be matched for conventional risk
factors for coronary artery disease (CAD) and to determine the relationship between CAC
scores and conventional and emerging risk factors for CAD.
n/a
Observational Model: Case Control, Time Perspective: Prospective
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