Impact of Peripheral Afferent Input on Central Neuropathic Pain

Status Not yet recruiting

Clinical Trial Summary

The overarching aim of this study is to investigate the contribution of peripheral afferent input to spontaneous and evoked central neuropathic pain after a spinal cord lesion or disease.

Clinical Trial Description

A key question that has been subject to longstanding debates in the field relates to the sites and mechanisms within the peripheral or central nervous system that potentially perpetuate chronic spontaneous and evoked central neuropathic pain. The investigators hypothesize that spontaneous central neuropathic pain depends on continuous, "physiological" somatosensory input from the painful body region in the periphery. Thus, spontaneous central neuropathic pain results from pathological gain control in central somatosensory networks with decreased activation thresholds for thermo- and mechanosensitive peripheral afferents. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05646810
Study type	Interventional
Source	University of Aarhus
Contact	Nanna B. Finnerup, Professor
Phone	0045 784 63380
Email	finnerup@clin.au.dk
Status	Not yet recruiting
Phase	N/A
Start date	December 1, 2022
Completion date	December 31, 2023

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