Spinal Cord Injuries Clinical Trial
Official title:
The Effect of Vaporized Cannabis on Neuropathic Pain in Spinal Cord Injury
This study will demonstrate that vaporized marijuana results in antinociception when compared to placebo in subjects with spinal cord injury. To further evaluate potential benefits and side effects, the effect of different strengths of cannabis on mood, cognition, and psychomotor performance will also be measured.
This study will demonstrate that vaporized cannabis can produce antinociceptive effects
compared to placebo in human subjects with spinal cord injury (SCI). A within-subject
crossover study of the effects of cannabis versus placebo on spontaneous and evoked pain
will be performed. A synopsis of antinociception with mood, cognitive impairment,
psychomotor performance, and side effects will be obtained to help evaluate the utility of
vaporized marijuana in SCI neuropathic pain.
This study will compare the analgesic and side effect profile of low (3.5%) to high dose
(7.0%) delta 9-tetrahydrocannabinol in subjects with spinal cord injury pain. It is
hypothesized that a low dose will produce a lesser degree of neuropsychological impairment
while maintaining a similar degree of pain relief to the higher dose. The use of two
different strengths will help determine tolerable dosing for the treatment of SCI
neuropathic pain.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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