Spinal Anesthesia Clinical Trial
Official title:
Isobaric Ropivacaine 15 mg Versus Hyperbaric Bupivacaine 12.5 mg for Spinal Anesthesia in Geriatric Patients Undergoing Total Knee Arthroplasty
The purpose of this study is to evaluate the efficacy and safety of spinal anesthesia with isobaric ropivacaine, compared with hyperbaric bupivacaine in geriatric patients undergoing lower limb orthopedic surgery.
52 patients physical status II-III according to the American Society of Anesthesiologists
classification aged 65 years and above of average height, and scheduled for total knee
replacement under spinal anesthesia.
Patients were randomly assigned into two equal groups of 26 patients each according to the
type of local anesthetic injected in the subarachnoid space , Group I : patients who
received an intrathecal injection of 12.5 mg of 0.5% hyperbaric bupivacaine , Group II:
patients who received an intrathecal injection of 15 mg of 0.5% ropivacaine.
The investigators compared both groups as regards the extent and duration of sensory and
motor block and hemodynamics including heart rate (HR) , non invasive mean arterial blood
pressure (MAP) and respiratory depression.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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