Compassionate Use Program for Olipudase Alfa Enzyme Replacement Therapy for Patients With Chronic Acid Sphingomyelinase Deficiency (ASMD)

Sphingomyelin Lipidosis Clinical Trial

Official title:

Compassionate Use Program for Olipudase Alfa Enzyme Replacement Therapy for Patients With Chronic Acid Sphingomyelinase Deficiency (ASMD)

Clinical Trial Details — Status: Available

Administrative data

• NCT number: NCT04799522
• Other study ID #: RHASHC09706
• Status: Available

Study information

• Verified date: March 2021
• Source: Sanofi
• Contact: Trial Transparency email recommended: Contact-US@sanofi.com OR T
• Phone: 800-633-1610
• Email: Contact-Us[@]sanofi.com
• Is FDA regulated: No
• Study type: Expanded Access

Clinical Trial Summary

The objective of this program is to provide access to enzyme replacement therapy (ERT) with olipudase alfa for certain patients with ASMD, a severe, life threatening disease, during the period between completion of the clinical trials necessary to support submission of a request for marketing authorization and receipt of a final response from the applicable regulatory authority in the country where this program is available.

Recruitment information / eligibility

• Status: Available
• Enrollment: 0
• Gender: All
• Age group: 3 Years and older

Eligibility

Inclusion Criteria:

All patients (adult and pediatric)

• Unsolicited request for the patient from a site with at least 3 years of experience in administration and safety management of ERT.

• Written informed consent signed by the patient or the patient's parent(s)/guardian(s), where applicable.

• Documented deficiency of acid sphingomyelinase in peripheral leukocytes, lymphocytes, or cultured fibroblasts.

Adult patients

• Age = 18 years.

• Clinically documented advanced disease evidenced by defined thresholds for lung, spleen, liver, and hematologic parameters.

Pediatric patients

• Age >3 years and <18 years or clinical diagnosis consistent with ASMD Type A/B or Type B.

Exclusion Criteria:

All patients (adult and pediatric)

• Active serious intercurrent illness which will preclude enrollment, significant liver disease with etiology other than ASMD, Malignancy with poor prognosis, serious medical or psychiatric condition that may preclude participation, or circumstances that may interfere with compliance in this compassionate use program, requirement for recurrent dose adjustment of anticoagulation treatment over the last 6 months.

• Pregnancy or breastfeeding.

• For female patients of childbearing potential, a positive serum pregnancy (ß human chorionic gonadotropin [HCG]) test result.

• For female patients of childbearing potential and sexually active male patients, unwillingness to abstain from heterosexual intercourse in accordance with their preferred and usual lifestyle, or to use 2 acceptable, effective contraceptive methods, while participating in this program and for 15 days after the last infusion of olipudase alfa.

• For pediatric patients, clinical diagnosis, or suspicion of infantile onset ASMD. Genotype compatible with ASMD type A.

Related Conditions & MeSH terms

• Niemann-Pick Disease, Type C
• Niemann-Pick Diseases
• Sphingomyelin Lipidosis

Intervention

Drug:
• olipudase alfa (GZ402665)
Patients will receive intravenous (IV) infusion of olipudase alfa

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Sanofi