Randomized Controlled Trial of Treating Hepatolithiasis (Accompanied With SOL) With Choledochojejunostomy

Hepatolithiasis Clinical Trial

Official title: Randomized Controlled Trial of Treating Hepatolithiasis(Accompanied With Sphincter of Oddi Laxity) With Roux-en-Y Choledochojejunostomy

Status Recruiting

Clinical Trial Summary

The purpose of this study is to determine whether Roux-en-Y choledochojejunostomy is a more effective treatment for the hepatolithiasis patients accompanied with Sphincter of Oddi Loose.

Clinical Trial Description

Hepatolithiasis (HL) is prevalent in East Asia, especially in China. While this condition results from multiple etiological factors, obstructive cholangitis is usually the main cause. In our clinical experience, the investigators have found few cases with obstruction of the common bile duct or sphincter of Oddi; to the contrary, almost half of our clinical cases showed sphincter of Oddi laxity (SOL). SOL results in reflux of duodenal fluid and Escherichia coli (E. coli) infection, which lead to the formation of stones in the biliary tract. Thus, HL tends to recur in SOL patients. For these patients, Roux-en-Y choledochojejunostomy(choledochojejunostomy with an anti-reflux ansa intestinalis) may be the most promising therapy. ;

Related Conditions & MeSH terms

• Hepatolithiasis
• Sphincter of Oddi Laxity

• NCT number: NCT01459549
• Study type: Interventional
• Source: Zhejiang University
• Contact: Liang TingBo, MD,PHD
• Phone: 086-571-87236688
• Email: liangtingbo@zju.edu.cn
• Status: Recruiting
• Phase: N/A
• Start date: October 2011
• Completion date: November 2020