Sperm Motility (Focus of Study) Clinical Trial
Official title:
Influence of Ribavirin and Interferon on Semen Quality, IRIS Study
The aim of this study is to study the effect of peginterferon alpha and ribavirin on spermatozoa.
During and six months after treatment with peginterferon alpha and ribavirin strict use of
birth control is recommended (the producers advice two reliable forms) for both men and
women because ribavirin has teratogenic and/or embryo-lethal effects in animal studies.
In cases of pregnancies during paternal exposure to peginterferon alpha and ribavirin
elective termination of the pregnancy is usually recommended. However three cases of births
after paternal exposure are reported with no birth defects. Cases of abnormalities after
paternal exposure to ribavirin are lacking.
Also studies on the influence of ribavirin on sperm in human are lacking.
The aim of this study is to study the effect of peginterferon alpha and ribavirin on
spermatozoa in men using these medication.
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Observational Model: Cohort, Time Perspective: Prospective