Sensory Memory in Speech Motor Learning

Speech Clinical Trial

Official title:

Role of Sensory Working Memory in Speech Motor Learning Aim 2

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04818268
• Other study ID #: 2000025475_a
• Secondary ID: R01DC017439
• Status: Recruiting
• Phase: N/A
• Start date: August 1, 2019
• Est. completion date: July 31, 2025

Study information

• Verified date: March 2024
• Source: Yale University
• Contact: David Ostry
• Phone: 2038656163
• Email: david.ostry[@]yale.edu
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The proposed studies focus on memory for speech movements and sounds and its relation to learning. Continuous theta-burst transcranial magnetic stimulation (cTBS) will be used to suppress activity in a region of pre-frontal cortex associated with somatic and auditory working memory (Brodmann area 46v) to test its involvement in learning.

Description:

This study will assess the relationship between sensory working memory and speech motor adaptation using a between subjects design. Participants will be assigned to one of two groups. Each group will undergo both auditory and somatosensory working memory tests. This will be followed by adaptation to altered auditory feedback. Using a different group of subjects, cTBS will be used to disrupt neural activity in Brodmann area 46v in ventrolateral prefrontal cortex to test its involvement in adaptation. One set of tests will focus on the effects of cTBS on both auditory and somatosensory working memory. A second set of tests will focus on the effects of cTBS on speech motor adaptation to altered auditory feedback. Both working memory and adaptation are assessed on 0 to 100 scales.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 120
• Est. completion date: July 31, 2025
• Est. primary completion date: July 31, 2025
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 21 Years to 40 Years

Eligibility

Inclusion Criteria:

• right handed adults
• no known physical or neurological abnormalities

Exclusion Criteria:

• patients with:
• cardiac pacemaker
• surgical clips or values on the heart
• implants
• metal or metallic fragments in any part of the body
• pregnancy
• claustrophobia
• a personal or family history of epilepsy
• currently taking antipsychotic drugs
• currently taking antidepressant drugs
• currently taking antianxiety drugs
• history of concussion.

Related Conditions & MeSH terms

• Consolidation
• Speech

Intervention

Behavioral:
• Adaptation
Sensorimotor adaptation in speech

Other:
• cTBS
continuous theta-burst stimulation

Locations

Country	Name	City	State
Canada	McGill University	Montréal	Quebec

Sponsors (2)

Lead Sponsor	Collaborator
Yale University	National Institute on Deafness and Other Communication Disorders (NIDCD)

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Speech Motor Learning	Learning is assessed on a 0 to 100 scale as change in speech sounds (speech formant frequencies). A score of 100 corresponds to complete adaptation.	Performance as measured at the end of learning (single day experiment)
Primary	Sensory Memory	Sensory Memory is measured on a 0 to 100 scale. A score of 100 corresponds to perfect memory.	Single day experiment