Sensory Basis of Speech Motor Learning

Speech Clinical Trial

Official title:

Brain Structures in Speech Motor Memory Consolidation

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04497428
• Other study ID #: 2000025475
• Secondary ID: R01DC017439
• Status: Recruiting
• Phase: N/A
• Start date: August 1, 2019
• Est. completion date: July 31, 2025

Study information

• Verified date: March 2024
• Source: Yale University
• Contact: David Ostry
• Phone: 2038656163
• Email: david.ostry[@]yale.edu
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

These studies test the hypothesis that sensory areas of the brain participate in the consolidation of speech motor memory by using transcranial magnetic stimulation to suppress activity in somatosensory and auditory cortex following adaptation in order to block retention of learning.

Description:

Subjects will train using either altered somatosensory feedback or altered auditory feedback (different groups of subjects). Immediately following adaptation, continuous theta burst magnetic stimulation (cTBS) will be applied to either auditory or somatosensory or motor cortex with the goal of blocking consolidation of motor memory. The logic of applying cTBS to both sensory areas is to test the hypothesis that both areas are involved in motor memory consolidation. Subjects leave the laboratory following cTBS and return 24 hours later to assess retention of learning. Learning is assessed as percentage change in speech sounds or movements relative to baseline. Retention is measured on a 0 to 100 scale relative to the end of learning.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 160
• Est. completion date: July 31, 2025
• Est. primary completion date: July 31, 2025
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 21 Years to 40 Years

Eligibility

Inclusion Criteria:

• right handed adults

• no known physical or neurological abnormalities

Exclusion Criteria:

• patients with:

• cardiac pacemaker

• surgical clips or values on the heart

• implants

• metal or metallic fragments in any part of the body

• pregnancy

• claustrophobia

• a personal or family history of epilepsy

• currently taking antipsychotic drugs

• currently taking antidepressant drugs

• currently taking antianxiety drugs

• history of concussion.

Related Conditions & MeSH terms

• Consolidation
• Speech

Intervention

Behavioral:
• Adaptation
Sensorimotor adaptation in speech

Other:
• cTBS
continuous theta-burst stimulation

Locations

Country	Name	City	State
Canada	McGill University	Montréal	Quebec

Sponsors (3)

Lead Sponsor	Collaborator
Yale University	McGill University, National Institute on Deafness and Other Communication Disorders (NIDCD)

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Motor Learning	Learning is assessed as percentage change in speech sounds (speech formant frequencies) or movements (movement curvature) relative to baseline.	Performance as measured at the end of learning (30 minute session)
Primary	Retention of Learning	Retention is measured on a 0 to 100 scale relative to the end of learning.	24 hours after learning (re-test lasts 30 minutes)