Specific Language Impairment (SLI) in Children May Caused by Epileptic Brain Activity

Specific Language Impairment Clinical Trial

Official title:

Specific Language Impairment (SLI) in Children May Caused by Epileptic Brain Activity

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04141332
• Other study ID #: Mansoura University Hospital
• Status: Completed
• Start date: February 1, 2018
• Est. completion date: March 1, 2019

Study information

• Verified date: October 2019
• Source: Mansoura University Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The objective of this study was to find if there is a possible association and the impact of epilepsy and epileptiform activity in children with SLI.

Description:

This study concentrates on the impact of epileptiform activity for childhood epilepsy on the speech and language disturbances in addition to the associated social, cognitive and intellectual dysfunctions.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 160
• Est. completion date: March 1, 2019
• Est. primary completion date: January 1, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 3 Years to 6 Years

Eligibility

Inclusion Criteria:

• 80 children were suffering from specific language impairment

• 80 healthy children with age and sex match control group.

Exclusion Criteria:

• Previous history of perinatal hypoxic-ischemic damage

• meningitis or encephalitis

• motor weakness

• hearing disorders

• IQ below seventy

• CP, social deprivation

• autism and

• psychiatric disorders .

Related Conditions & MeSH terms

• Language Disorders
• Specific Language Impairment

Intervention

Diagnostic Test:
• EEG was recorded by EEG Machines
EEG was recorded by EEG Machines

Locations

Country	Name	City	State
Egypt	Mansoura University Hospital	Mansoura	Dakahlia

Sponsors (1)

Lead Sponsor	Collaborator
Mansoura University Hospital

Country where clinical trial is conducted

Egypt, 

References & Publications (30)

2-Kraft, S.J. & De Thorne, L.S. The Brave New World of Epigenetics: Embracing Complexity in the Study of Speech and Language Disorders Current Developmental Disorders Reports . 2014; 1: 207.

3-Hillert, Dieter. Encyclopedia of Evolutionary Psychological Science, Chapter: Neurobiology of Language, Publisher: Springer, Editors Viviana Weekes-Shackelford, Todd K. Shackelford, Viviana A. Weekes-Shackelford. Neurobiology of Language.2016: pp.1-15

Baumer FM, Cardon AL, Porter BE. Language Dysfunction in Pediatric Epilepsy. J Pediatr. 2018 Mar;194:13-21. doi: 10.1016/j.jpeds.2017.10.031. Epub 2017 Dec 11. Review. — View Citation

Carol Westby. Social-Emotional Outcomes for Children With SLI . Word of Mouth. 2017 ; 28 (4):1-5.

El-Maghraby R. Comprehensive Arabic Language test as a tool for assessing delayed language impaired Egyptian children [MD thesis]. Alexandria: Faculty of Medicine, Alexandria University;2008.

Fadhli, Khadija & Al-Bunaian, Nada. Prevalence and Social Influences of Delayed Language Development in Preschool-Age Saudi Children. International Journal of Science and Research. 2017:6. 6-391.

Faught E, Karakis I, Drane DL. The Impact of Interictal Discharges on Performance. Curr Neurol Neurosci Rep. 2018 Oct 8;18(12):88. doi: 10.1007/s11910-018-0892-9. Review. — View Citation

Ghacibeh GA, Fields C. Interictal epileptiform activity and autism. Epilepsy Behav. 2015 Jun;47:158-62. doi: 10.1016/j.yebeh.2015.02.025. Epub 2015 Apr 3. Review. — View Citation

Ghandour H, Eldin SK, Sallam Y, Mahmoud S. Associated comorbidities of specific language impairment. Benha Med J. 2018; 35:115-21.

Hamdy M. Bedair, Mona K. Mohamed, Rania M. Abdou, Faten I. El Kafrawy. Concurrent language disorders in children with idiopathic epilepsy. Egyptian Journal of Otolaryngology. 2017: 33 (3): 603-609.

Holmes GL. What is more harmful, seizures or epileptic EEG abnormalities? Is there any clinical data? Epileptic Disord. 2014 Oct;16 Spec No 1:S12-22. doi: 10.1684/epd.2014.0686. Review. — View Citation

Jones JE, Siddarth P, Gurbani S, Shields WD, Caplan R. Cognition, academic achievement, language, and psychopathology in pediatric chronic epilepsy: Short-term outcomes. Epilepsy Behav. 2010 Jul;18(3):211-7. doi: 10.1016/j.yebeh.2010.03.015. Epub 2010 May — View Citation

Kalnak N, Peyrard-Janvid M, Sahlén B, Forssberg H. Family history interview of a broad phenotype in specific language impairment and matched controls. Genes Brain Behav. 2012 Nov;11(8):921-7. doi: 10.1111/j.1601-183X.2012.00841.x. Epub 2012 Sep 20. — View Citation

Kane N, Acharya J, Benickzy S, Caboclo L, Finnigan S, Kaplan PW, Shibasaki H, Pressler R, van Putten MJAM. A revised glossary of terms most commonly used by clinical electroencephalographers and updated proposal for the report format of the EEG findings. — View Citation

Kim EH, Ko TS. Cognitive impairment in childhood onset epilepsy: up-to-date information about its causes. Korean J Pediatr. 2016 Apr;59(4):155-64. doi: 10.3345/kjp.2016.59.4.155. Epub 2016 Apr 30. Review. — View Citation

Laasonen M, Smolander S, Lahti-Nuuttila P, Leminen M, Lajunen HR, Heinonen K, Pesonen AK, Bailey TM, Pothos EM, Kujala T, Leppänen PHT, Bartlett CW, Geneid A, Lauronen L, Service E, Kunnari S, Arkkila E. Understanding developmental language disorder - the — View Citation

Luz-Escamilla L, Morales-González JA. Association between Interictal Epileptiform Discharges and Autistic Spectrum Disorder. Brain Sci. 2019 Jul 30;9(8). pii: E185. doi: 10.3390/brainsci9080185. — View Citation

McTague A, Howell KB, Cross JH, Kurian MA, Scheffer IE. The genetic landscape of the epileptic encephalopathies of infancy and childhood. Lancet Neurol. 2016 Mar;15(3):304-16. doi: 10.1016/S1474-4422(15)00250-1. Epub 2015 Nov 17. Review. — View Citation

Mehta B, Chawla VK, Parakh M, Parakh P, Bhandari B, Gurjar AS. EEG Abnormalities in Children with Speech and Language Impairment. J Clin Diagn Res. 2015 Jul;9(7):CC04-7. doi: 10.7860/JCDR/2015/13920.6168. Epub 2015 Jul 1. — View Citation

Moreno MA. Speech and Language Delays in Young Children. JAMA Pediatr. 2015 Aug;169(8):796. doi: 10.1001/jamapediatrics.2014.2146. — View Citation

Parry-Fielder B, Collins K, Fisher J, Keir E, Anderson V, Jacobs R, Scheffer IE, Nolan T. Electroencephalographic abnormalities during sleep in children with developmental speech-language disorders: a case-control study. Dev Med Child Neurol. 2009 Mar;51( — View Citation

Reilly S, Tomblin B, Law J, McKean C, Mensah FK, Morgan A, Goldfeld S, Nicholson JM, Wake M. Specific language impairment: a convenient label for whom? Int J Lang Commun Disord. 2014 Jul-Aug;49(4):416-51. doi: 10.1111/1460-6984.12102. Review. — View Citation

Sánchez Fernández I, Loddenkemper T, Galanopoulou AS, Moshé SL. Should epileptiform discharges be treated? Epilepsia. 2015 Oct;56(10):1492-504. doi: 10.1111/epi.13108. Epub 2015 Aug 21. Review. — View Citation

Shweta Singh, Shivani Pandey, Vivek Agarwal. A Comparative study of Vineland Adaptive Behavior Scale II and Vineland Social Maturity Scale on children and adolescents with Intellectual Disability J. Indian Assoc. Child Adolesc. Ment. Health 2019; 15(1):27

Staley K. Molecular mechanisms of epilepsy. Nat Neurosci. 2015 Mar;18(3):367-72. doi: 10.1038/nn.3947. Epub 2015 Feb 24. Review. — View Citation

Syam UK, Thomas SV. Epileptiform activity in the electroencephalogram of 6-year-old children of women with epilepsy. Ann Indian Acad Neurol. 2016 Jul-Sep;19(3):318-22. doi: 10.4103/0972-2327.179974. — View Citation

Tomas E, Vissers C. Behind the Scenes of Developmental Language Disorder: Time to Call Neuropsychology Back on Stage. Front Hum Neurosci. 2019 Jan 9;12:517. doi: 10.3389/fnhum.2018.00517. eCollection 2018. Review. — View Citation

Tuchman R. Autism and Cognition Within Epilepsy: Social Matters. Epilepsy Curr. 2015 Jul-Aug;15(4):202-5. doi: 10.5698/1535-7511-15.4.202. — View Citation

Ung H, Cazares C, Nanivadekar A, Kini L, Wagenaar J, Becker D, Krieger A, Lucas T, Litt B, Davis KA. Interictal epileptiform activity outside the seizure onset zone impacts cognition. Brain. 2017 Aug 1;140(8):2157-2168. doi: 10.1093/brain/awx143. — View Citation

Wallace IF, Berkman ND, Watson LR, Coyne-Beasley T, Wood CT, Cullen K, Lohr KN. Screening for Speech and Language Delay in Children 5 Years Old and Younger: A Systematic Review. Pediatrics. 2015 Aug;136(2):e448-62. doi: 10.1542/peds.2014-3889. Epub 2015 J — View Citation

* Note: There are 30 references in all — Click here to view all references

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Intelligence quotient (IQ)	An intelligence quotient (IQ) is a total score derived from several standardized tests designed to assess human intelligence. Historically, IQ is a score obtained by dividing a person's mental age score, obtained by administering an intelligence test, by the person's chronological age, both expressed in terms of years and months. The resulting fraction is multiplied by 100 to obtain the IQ score.; When current IQ tests were developed, the median raw score of the norming sample is defined as IQ 100 and scores each standard deviation (SD) up or down are defined as 15 IQ points greater or less.	24-72 hours
Other	social age	Evaluation of social age: using the Vineland Social Maturity Scale . VSMS was used along with a cognitive assessment to help make a diagnosis of mental retardation or intellectual disability. It has also been used extensively to assess the development of activities of everyday life.	24-48 hours
Other	cognitive age	Evaluation of cognitive age (mental age): using the Stanford Binet Intelligence Scale. The Stanford-Binet test is a examination meant to gauge intelligence through five factors of cognitive ability. These five factors include fluid reasoning, knowledge, quantitative reasoning, visual-spatial processing and working memory. Both verbal and nonverbal responses are measured.	24-48 hours
Other	language assessment	Language evaluation: by Comprehensive Arabic Language Test (CALT). The CALT was constructed by the members of the Department of Phoniatrics at Alexandria Main University Hospital, Egypt, to form a detailed comprehensive assessment battery for Arabic language and test its reliability and validity to use it in the early detection of subtle changes in the various components of language in cases of language impaired children.	24-72 hours
Primary	EEGs finding	EEGs finding were defined according to the followings "Normal: within the range of frequency and amplitude distribution." "Epileptiform: Describes transient background activity with a characteristic spikes, sharp waves, spike-slow wave or sharp-slow wave complexes of focal or generalized distribution".; "Abnormal non-epileptiform: deviations from normal in terms of background frequency patterns, usually in the form of excessive slow activity".	24-48 hours