Cognitive Disorders in Hereditary Spastic Paraplegia Type 4 — SPG-TEP  

Spastic Paraplegia Clinical Trial

Official title: Cognitive Disorders and Metabolism in 18-FDG- PET in Hereditary Spastic Paraplegia Type 4 (SPG4)

Status Recruiting

Clinical Trial Summary

Hereditary spastic paraplegia type 4 is the most frequent mutation of hereditary spastic paraplegias. It is commonly described as pure, with progressive weakness of the lower limbs, pyramidal syndrome and vesico-sphincter disorders. However, cognitive disorders have been reported for over 20 years, but remain poorly characterized.

Clinical Trial Description

Our primary objective is to describe a pattern of cognitive impairment in Hereditary Spastic Paraplegia type 4 using 18-FDG-PET metabolic imaging.

As secondary objectives, we wish to study the presence of correlations between neuropsychological tests, clinical examination, 18-FDG-PET data and general and genetic data of the pathology. We also wish to investigate correlations between genotype and phenotype. ;

Related Conditions & MeSH terms

• Cognition Disorders
• Cognitive Dysfunction
• Muscle Spasticity
• Paraplegia
• Spastic Paraplegia
• Spastic Paraplegia, Hereditary

• NCT number: NCT06260982
• Study type: Observational [Patient Registry]
• Source: Central Hospital, Nancy, France
• Contact: Mathilde Renaud
• Phone: +333 83 85 17 80
• Email: m.renaud2@chru-nancy.fr
• Status: Recruiting
• Start date: January 1, 2022
• Completion date: January 2, 2025