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Spasm clinical trials

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NCT ID: NCT06447688 Recruiting - Radial Artery Spasm Clinical Trials

Does Verapamil Given Orally Prevent Radial Artery Spasm During Transradial Coronary Angiography

Start date: June 5, 2024
Phase: Phase 4
Study type: Interventional

Coronary angiography (CAG) is an invasive imaging method performed to determine the degree of coronary artery disease. Radial artery spasm (RAS) is one of the most common complications during coronary angiography performed via the transradial approach, causing patient discomfort or sometimes interrupting the procedure. There are many studies on RAS, and various pharmacoagents administered intravenously (intraarterial) to prevent RAS have been described. However, there is limited data in the literature regarding oral pharmacoagents that will prevent this complication. In our study, the preventive effect of Verapamil, given orally 2 hours before coronary angiography, on radial artery spasm will be investigated.

NCT ID: NCT06441253 Active, not recruiting - Spasm Clinical Trials

Development and Evaluation of a Portable Wedge Device for Calf Stretching to Alleviate Strain and Spasms

Start date: November 1, 2023
Phase: N/A
Study type: Interventional

This research aimed to contribute valuable insights into the potential benefits of incorporating the portable wedge device into preventive or therapeutic interventions for calf-related musculoskeletal issues.

NCT ID: NCT06432452 Not yet recruiting - Coronary Spasm Clinical Trials

Efficacy of Endothelin Receptor Antagonism in Coronary Artery Spasm

EDIT-CAS
Start date: August 1, 2024
Phase: Phase 2/Phase 3
Study type: Interventional

The goal of this randomized clinical trial is to assess if adjunctive bosentan therapy, in comparison to placebo, can reduce the rate of epicardial vasospasm at follow-up spasm provocation CFT (fuCFT) in patients with previously proven epicardial vasospasm on acetylcholine reactivity testing (at index CFT) and ongoing angina(-like) complaints. Participants will - Use either endothelin receptor antagonist or placebo for 10 weeks - Undergo follow-up acetylcholine spasm provocation test after 10 weeks - Answer online questionnaires on angina and quality of life

NCT ID: NCT06408766 Not yet recruiting - Clinical trials for Smartphone Addiction

Investigating the Effects of Smartphone Use on the Masseter Muscle

Start date: May 30, 2024
Phase:
Study type: Observational

The aim of this study was to determine the short- and long-term effects of smartphone use on the masseter muscle. In the short term, to investigate whether repetitive thumb movements during phone use will cause a spontaneous muscle activation and/or tenderness in the masseter muscle; in the long term, to investigate the relationship between strength change and tenderness of the tenar and masseter muscles depending on the intensity and duration of phone use.

NCT ID: NCT06315829 Not yet recruiting - Infantile Spasms Clinical Trials

Artificial Intelligence-based Video Analysis to Detect Infantile Spasms

Start date: August 2024
Phase:
Study type: Observational

Infantile spasms are a type of seizure linked to developmental issues. Unfortunately, they are often misdiagnosed, causing delays in treatment. The purpose of this study is to develop a computer program that can reliably differentiate infantile spasms from similar, yet benign movements in videos. This computer program will learn from videos taken by parents of study participants. Quickly recognizing and treating infantile spasms is crucial for ensuring the best developmental outcomes.

NCT ID: NCT06227676 Completed - Clinical trials for Polycystic Ovary Syndrome

Effect of 'Cramp Bites' on Period Cramps in Women Aged 18-25

NUTRITION; GYN
Start date: July 21, 2022
Phase: Phase 2/Phase 3
Study type: Interventional

85 percent of women of reproductive age experience consistent period cramps/menstrual pain, and 60% indicate that they do not use painkillers to relieve menstrual symptoms; there is a need for natural and non-medicative supplements to dysmenorrhea. The purpose of this clinical trial is to examine the effect of 'Cramp Bites'--classified by a mixture of natural ingredients researched to help with period pain--on women suffering from primary dysmenorrhea: this will be done through providing participants with the snack and surveying them on how it changes their period symptoms.

NCT ID: NCT06195241 Not yet recruiting - Hemifacial Spasm Clinical Trials

Effects of DaxibotulinumtoxinA for Blepharospasm and Hemifacial Spasm

Start date: July 2024
Phase: Phase 4
Study type: Interventional

The goal of this clinical trial is to test the effects of DaxibotulinumtoxinA-Lanm (Daxxify) in patients with benign essential blepharospasms (BEB) and hemifacial spasms (HFS). The main questions to answer: 1. Is there clinically significant difference (measured by Jankovic Rating Scale (JRS) score from base to peak efficacy) for patients with BEB and HFS treated with Daxxify? 2. What percentage of patients achieve a clinical response? Participants historically treated with Botox for either BEB or HFS will be crossed over to Daxxify treatment in order to serve as their own control and examine the efficacy of Daxxify.

NCT ID: NCT05980637 Not yet recruiting - Clinical trials for Sleep-related Leg Cramps

Effectiveness and Safety of Shaoyao Gancao Decoction With Addition on the Sleep-related Leg Cramps

Start date: September 1, 2023
Phase: Phase 2/Phase 3
Study type: Interventional

A randomized, double-blinded, placebo-controlled clinical trial using a Chinese Medicine formula in treating Sleep-related Leg Cramps. Subjects will be randomized into a treatment group or placebo group for 4 weeks, and then post-treatment visit at week 6 and week 8.

NCT ID: NCT05958160 Recruiting - Clinical trials for Epileptic Spasms, Failed Hormonal Therapy

Modified Atkins Diet Versus Topiramate In Children With Epileptic Spasms Refractory To Hormonal Treatment: A Randomized Open-Label Study

TOPAMAD
Start date: July 20, 2023
Phase: Phase 2/Phase 3
Study type: Interventional

This study has been planned to compare the efficacy and tolerability of topiramate, a commonly used second line agent, with modified Atkins diet in children with epileptic spasms refractory to hormonal treatment, in a randomized open label study.

NCT ID: NCT05861765 Recruiting - Radial Artery Spasm Clinical Trials

The Efficacy of Papaverine to Prevent Radial Artery Spasm During Transradial Cerebral Angiography

PASS
Start date: May 24, 2023
Phase: Phase 2
Study type: Interventional

Rationale:Papaverine is effective on radial artery spasm during transradial cerebral angiography. Purpose: This multicenter, randomized, placebo-controlled, double blind, phase 2b trial aims to investigate the effect and safety of papaverine in treating radial artery spasm during transradial cerebral angiography.