Subjective Perception of Motor Control During Psychogenic Disorders

Somatoform Disorders Clinical Trial

— PERCMO-TNF  

Official title:

Study of Subjective Perception of Motor Control During Psychogenic Disorders : Brain Mechanisms and Functional Imaging.

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT02843932
• Other study ID #: 38RC14.120*
• Status: Terminated
• Phase: N/A
• Start date: May 13, 2015
• Est. completion date: June 2019

Study information

• Verified date: November 2020
• Source: University Hospital, Grenoble
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The aim of this study is to reveal neurobiological bases of the motor control of conscious perception, thanks to new techniques of functional cerebral imaging (MRI), and potentials deteriorations connected to neuropsychiatric disorders like conversion disorder.

The Hospital University Center of Grenoble will provide patients from Neurology department, characterized with non psychogenic epileptic seizures and abnormal psychogenic movements, from conversive origin.

Subjects will be scanned by Magnetic Resonance Imaging during a motor paradigm inducing a perceptive conflict between two informations : proprioceptive information coming from the action (drawing) and visual information (draw's mark) that appears on the screen when there is movement.

Description:

New results will be provided about brain mechanisms involved in motor control perception among healthy patients and patients suffering from functional neurologic symptoms.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 14
• Est. completion date: June 2019
• Est. primary completion date: June 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• Signed informed consent

• Medical exam médical done before study participation

• Between 18 and 65 years

• Right-handed persons

• Conversion disorder based on DSM IV-R criterias

• Symptom affecting motor system, like abnormal movements (shivers, dystonia, parkinsonism, or problem when walking)

Exclusion Criteria:

• Subjects included in a clinical and/or therapeutic exeprimentation in progress

• People with MRI contraindications : prosthesis or metal implants, metallic teeth (dental) brace, pacemaker, IUD, possibility of pregnancy, claustrophobia

• Traitement médicamenteux psychotrope ou susceptible d'interférer avec le débit sanguin cérébral ou l'activité neuronale

• History of brain or disseminated and extendible lesions of white matter, of an other degenerative morbidity, a confusion or an insanity as well as serious deficits preventing language understanding.

• Alcohol ingestion

• Pregnant, parturient or breastfeeding women

• All other categories of protected persons

Related Conditions & MeSH terms

• Somatoform Disorders

Intervention

Other:
• functional brain MRI
functional imagery during motor-perception tasks

Locations

Country	Name	City	State
France	Chu Grenoble	Grenoble

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Grenoble

Country where clinical trial is conducted

France, 

References & Publications (17)

Blakemore SJ, Wolpert DM, Frith CD. Abnormalities in the awareness of action. Trends Cogn Sci. 2002 Jun 1;6(6):237-242. — View Citation

Carson AJ, Stone J, Warlow C, Sharpe M. Patients whom neurologists find difficult to help. J Neurol Neurosurg Psychiatry. 2004 Dec;75(12):1776-8. — View Citation

Cojan Y, Vuilleumier P. Functional brain imaging of psychogenic paralysis during conversion and hypnosis

Cojan Y, Waber L, Carruzzo A, Vuilleumier P. Motor inhibition in hysterical conversion paralysis. Neuroimage. 2009 Sep;47(3):1026-37. doi: 10.1016/j.neuroimage.2009.05.023. Epub 2009 May 18. — View Citation

de Lange FP, Roelofs K, Toni I. Increased self-monitoring during imagined movements in conversion paralysis. Neuropsychologia. 2007 May 15;45(9):2051-8. Epub 2007 Feb 11. — View Citation

de Lange FP, Roelofs K, Toni I. Motor imagery: a window into the mechanisms and alterations of the motor system. Cortex. 2008 May;44(5):494-506. doi: 10.1016/j.cortex.2007.09.002. Epub 2007 Dec 23. — View Citation

Desmurget M, Grafton S. Forward modeling allows feedback control for fast reaching movements. Trends Cogn Sci. 2000 Nov 1;4(11):423-431. — View Citation

Fourneret P, Jeannerod M. Limited conscious monitoring of motor performance in normal subjects. Neuropsychologia. 1998 Nov;36(11):1133-40. — View Citation

Friston KJ, Holmes AP, Worsley KJ. How many subjects constitute a study? Neuroimage. 1999 Jul;10(1):1-5. — View Citation

Ghez C, Hening W, Gordon J. Organization of voluntary movement. Curr Opin Neurobiol. 1991 Dec;1(4):664-71. Review. — View Citation

Hallet M, cloninger CR, Fahn S, Halligan P, Jankovic J, Lang AE, Voon V Psychogenic movement disorders and other conversion disorders. Cambridge University Press 2011

Rothwell JC, Traub MM, Day BL, Obeso JA, Thomas PK, Marsden CD. Manual motor performance in a deafferented man. Brain. 1982 Sep;105 (Pt 3):515-42. — View Citation

Sabes PN. The planning and control of reaching movements. Curr Opin Neurobiol. 2000 Dec;10(6):740-6. Review. — View Citation

Stone J, Carson A, Sharpe M. Functional symptoms in neurology: management. J Neurol Neurosurg Psychiatry. 2005 Mar;76 Suppl 1:i13-21. Review. — View Citation

van Beers RJ, Baraduc P, Wolpert DM. Role of uncertainty in sensorimotor control. Philos Trans R Soc Lond B Biol Sci. 2002 Aug 29;357(1424):1137-45. Review. — View Citation

Vuilleumier P, Chicherio C, Assal F, Schwartz S, Slosman D, Landis T. Functional neuroanatomical correlates of hysterical sensorimotor loss. Brain. 2001 Jun;124(Pt 6):1077-90. Erratum in: Brain. 2016 May;139(Pt 5):e29. — View Citation

Wolpert DM, Ghahramani Z, Jordan MI. An internal model for sensorimotor integration. Science. 1995 Sep 29;269(5232):1880-2. — View Citation

* Note: There are 17 references in all — Click here to view all references

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Familiarization with the joystick.	HHSC-JOY-I from Current Designs. They are asked to trace a straight line.	30 minutes
Primary	Brain MRI		One hour and a half