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Study of Dextromethorphan in OCD and Related Disorders

Obsessive-Compulsive Disorder Clinical Trial

Official title:
Fluoxetine/Dextromethorphan in Obsessive-Compulsive and Related Disorders: an Open-Label Crossover Pilot Study

Clinical Trial Summary

The purpose of the study is to assess the tolerability and efficacy of dextromethorphan in combination with fluoxetine for symptom relief in OCD and related disorders.

Clinical Trial Description

Obsessive compulsive disorder (OCD) and the related disorders body dysmorphic disorder (BDD), somatic symptom disorder (SSD) and illness anxiety disorder (IAD) are psychiatric conditions characterized by recurrent, intrusive thoughts, feelings or images (obsessions or preoccupations) and repetitive or ritualized behaviors or avoidance performed to relieve obsession or preoccupation-related anxiety. They are a significant cause of mental health-related disability, and are inadequately served by available treatments. This study tests whether an over-the-counter cough suppressant medicine, dextromethorphan, may offer symptom relief when combined with a low dose of fluoxetine, a standard prescription treatment for OCD and related disorders. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04899687
Study type Interventional
Source Stanford University
Contact Pavithra Mukunda, MS
Phone 650 497 2578
Email ocdresearch@stanford.edu
Status Recruiting
Phase Phase 2
Start date January 20, 2022
Completion date December 1, 2025
View Details
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