Solid Tumors Clinical Trial
Official title:
Association of Genetic Polymorphisms With Docetaxel-based Chemotherapy Toxicities in Chinese Solid Tumor Patients
Taxanes are one of the most active agents in the treatment of many kinds of solid tumors,
mainly including paclitaxel and docetaxel. However, variability in toxicity and response
remains a major problem for patients receiving taxanes. It is general that there are many
factors for individual differences of drugs in clinical application, of which genetic factors
accounted for more than 20%. Toxicities of docetaxel, such as myelosuppression, neurotoxicity
or mucositis, were evaluated for possible relationship with pharmacogenetic polymorphisms in
several candidate gene and genome-wide association studies. Due to the levels of evidence of
those studies are low and lack of sufficient research data of Chinese, it has the important
significance in studying individual differences of docetaxel in toxicities, through the
pharmacogenomics research.
The aim of this study is to evaluating the association genetic polymorphisms with
docetaxel-based chemotherapy toxicities in chinese solid tumor patients. By detecting the
gene polymorphism, investigators intend to study the pharmacokinetic/pharmacogenomics (PK-PG)
correlation of docetaxel and provide scientific basis for precise medication guide for people
to use docetaxel.
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