Solid Tumors Clinical Trial
Official title:
A Single Arm, Open, Phase I/II Clinical Study of MASCT-I Treatment for Advanced Solid Tumor
Multiple Target Antigen Stimulating Cell Therapy (MASCT-I) is a new immunotherapy that
dendritic cells(DC) was induced from autologous peripheral blood. The DC can then be loaded
with antigens and re-infused. In vitro, antigen-pulsed DC can stimulate autologous T-cell
proliferation and induction of autologous specific cytotoxic T-cells(CTL)，similarly
re-infused. The previous research data showed that MASCT had the modest overall response and
less adverse effects for Hepatocellular Carcinoma patients.
The study is aimed to evaluate the safety of MASCT-1 in patients with advanced solid tumors.
This study is divided into two stages. The first stage is the safety study in small samples,
and the second stage is the sample size expansion phase.
40-50 patients with advanced or recurrent solid tumors who had failed after standard
treatment will be recruited in this study.
;
Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Supportive Care
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