Solid Tumors Clinical Trial
Official title:
A Phase 1 Study to Investigate the Absorption, Metabolism and Excretion of [14C]ASP8273 in Subjects With Solid Tumors Harboring Epidermal Growth Factor Receptor (EGFR) Mutations
This is a study to investigate the absorption, metabolism and excretion of [14C] labeled ASP8273 in subjects with solid tumors harboring EGFR mutations (per local testing). This study consists of two parts (A and B).
This study consists of two parts (A and B).
In Part A, eligible subjects will be admitted to the site on day -1 and remain confined at
the site until postdosing discharge criteria are met. Subjects will receive a single dose of
[14C] ASP8273 solution on study day 1.
Once Part A has been completed, subjects may elect to continue participation in Part B.
Subjects will receive oral administration of ASP8273 (nonradiolabeled) once daily in 28-day
cycles.
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|---|---|---|---|
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