A Phase I/IIa Open-Label, Dose Escalation & Cohort Expansion Trial of Oral

Clinical Trial Summary

TSR-011 is a potent small molecule inhibitor of tyrosine kinases involved in cancer, including:

1. Anaplastic lymphoma kinase (ALK)

2. The tropomyosin-related kinases TRKA, TRKB, and TRKC

This is a sequential, open-label, non-randomized study with dose escalation in Phase 1, followed by expansion at a recommended phase 2 dose.

See also
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NCT number	NCT02048488
Study type	Interventional
Source	Tesaro, Inc.
Contact
Status	Completed
Phase	Phase 1/Phase 2
Start date	October 2012
Completion date	June 2018

A Phase I/IIa Open-Label, Dose Escalation and Cohort Expansion Trial of Oral TSR-011 in Patients With Advanced Solid Tumors and Lymphomas

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms