Cardiac Safety Assessment Study of Picoplatin in Solid Tumors

Solid Tumors Clinical Trial

Official title:

A Phase 1 Study of Picoplatin in Subjects With Advanced Non-Hematological Malignancies With Emphasis on Cardiac Repolarization

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT00710697
• Other study ID #: 0701
• Status: Active, not recruiting
• Phase: Phase 1
• First received: July 2, 2008
• Last updated: September 23, 2009
• Start date: June 2008
• Est. completion date: July 2009

Study information

• Verified date: September 2009
• Source: Poniard Pharmaceuticals
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Food and Drug Administration
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to investigate what effects, if any, picoplatin has on the heart rhythm.

Description:

Phase 1 and 2 studies have demonstrated that picoplatin, a next-generation platinum analogue designed to avoid drug resistance, has activity when administered IV in a variety of cancers. Preclinical and clinical studies indicate that picoplatin may be effective in platinum refractory or resistant cancer.

Preclinical data in beagle dogs have shown that picoplatin had no effect on cardiovascular function, including the QT interval. In the cumulative human trial experience, the cardiovascular serious adverse events that have occurred are consistent with events expected in patients with advanced malignant disease and do not suggest any propensity toward drug-related serious ventricular arrhythmias or sudden death.

The purpose of this trial is to conduct a formal study to specifically evaluate the effect of picoplatin on the QT/QTc interval as measured by the ECG, and to correlate QTcF interval with plasma total and ultrafilterable platinum concentrations. This study is also being conducted to ensure the safety of picoplatin with regard to the QT/QTc interval. Patients who choose to participate in this study will also be given the opportunity to continue to receive picoplatin until limited by toxicity or disease progression.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 40
• Est. completion date: July 2009
• Est. primary completion date: March 2009
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Documented histological or cytological diagnosis of non-hematological malignancy.

• Subjects for whom, in the opinion of the investigator, treatment with single agent picoplatin is appropriate.

• 18 years of age or older.

• ECOG performance status 0-2.

• An acceptable screening ECG.

• The following laboratory values:

• ANC = 1500 cells/mm3 (without use of myeloid growth factors).

• Hemoglobin = 10.0 g/dL (may be achieved with transfusion or growth factors).

• Platelet count = 100,000/mm3 (without platelet transfusions in the past 10 days).

• Serum creatinine = 1.5 x ULN.

• Total bilirubin = 1.5 x ULN.

• AST/SGOT and ALT/SGPT = 2.5 x ULN (up to 5.0 x ULN in the event of documented hepatic tumor involvement).

• Serum potassium and magnesium within institutional normal limits. PT, aPTT = 1.2 x ULN.

• Recovery period = 4 weeks since major surgery, any chemotherapy (= 6 weeks for treatment with mitomycin or any nitrosourea), any biological therapy, any investigational therapy or any change in usage of "alternative therapies".

• Recovery period = 2 weeks since any radiation therapy.

• Willing, available and able to comply with all protocol requirements including dietary schedule and restrictions.

• Written informed consent obtained prior to any screening procedures.

Exclusion Criteria:

• Symptomatic or uncontrolled brain metastases.

• Use of conventional granulocyte growth factors within the preceding 10 days or pegfilgrastim within the past 21 days.

• Any concurrent severe and/or uncontrolled medical conditions which could compromise participation in the study. For example,

• Unresolved toxicities from prior treatments of > Grade 1 (other than alopecia).

• Clinically significant infection.

• Known viral infections with hepatitis B or C or HIV.

• Clinically significant psychiatric illness.

• Any other systemic or localized disease or therapy likely to interfere with tolerance of chemotherapy or requirements of study participation.

• History of unexplained syncope within the last two months or a family history of sudden unexplained death.

• Cardiac contraindications to study participation, including:

• History of serious cardiac disease, defined as myocardial infarction within three months of enrollment, congestive heart failure classified by the New York Heart Association as Class III or IV, clinically significant cardiac arrhythmias, poorly controlled or unstable angina or electrocardiographic evidence of acute ischemia.

• Implantable pacemaker or automatic implantable cardioverter defibrillator.

• Congenital long QT syndrome or family history of long QT syndrome.

• If male, QTc > 450 ms; if female, QTc > 460 ms.

• PR duration > 240 ms; QRS > 110 ms. Complex arrhythmias (significant ventricular tachycardia, Mobitz block, bifascicular AV block) on the screening ECG.

• Atrial fibrillation or flutter. Complete left bundle branch block; use of an obligate pacemaker.

• Current use of anticoagulants or anti-platelet drugs, including aspirin, warfarin, enoxaparin, clopidogrel, or heparin (use of heparin for central venous port maintenance is acceptable).

• Ongoing bleeding or history of clinically significant bleeding within the last 6 months (unless the etiology of the prior bleeding has been identified and corrected).

• Concurrent medications that prolong the QT interval (including cisapride, erythromycin, antipsychotics or tricyclic antidepressants, quinidine, procainamide, disopyramide, amiodarone or sotalol), or any agent classified as either "Drugs with Risk of Torsades de Pointes" or "Drugs with Possible Risk of Torsades de Pointes" on the website www.torsades.org.

• Female subjects who are pregnant or breast feeding.

• Subjects of reproductive potential not willing to use an effective method of contraception during the study (from first day of and until 1 month after study drug administration).

• Conditions that may interfere with QTc analysis:

• Allergy to ECG electrodes.

• Any condition that impairs the placement of ECG electrodes or the interpretation of ECGs (including but not limited to breast implants).

Study Design

Endpoint Classification: Pharmacodynamics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Solid Tumors

Intervention

Drug:
• Picoplatin
IV 150 mg/m2, IV (in the vein) on day 1 of each 21 day cycle. Number of Cycles: until progression or unacceptable toxicity develops.

Locations

Country	Name	City	State
United States	UNM Cancer Center	Albuquerque	New Mexico
United States	Georgia Cancer Specialists	Atlanta	Georgia
United States	Moores UCSD Cancer Center	La Jolla	California
United States	Premiere Oncology	Santa Monica	California
United States	Premiere Oncology of Arizona	Scottsdale	Arizona
United States	Swedish Cancer Institute	Seattle	Washington
United States	Northwest Medical Specialities	Tacoma	Washington

Sponsors (1)

Lead Sponsor	Collaborator
Poniard Pharmaceuticals

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	ECG interval change		24 hours	Yes
Secondary	Safety/Efficacy		24 hours	Yes