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Study of the RNR Inhibitor BBI-825 in Subjects With Tumors With Resistance Gene Amplifications — STARMAP  

Solid Tumor Clinical Trial

Official title:
An Open-Label, Multicenter, First-in-Human, Dose-Escalation and Dose-Expansion, Phase 1/2 Study of BBI-825 and BBI-825 in Combination With Select Targeted Therapies in Subjects With Locally Advanced or Metastatic Solid Tumors With Resistance Gene Amplifications

Clinical Trial Summary

BBI-825 is a potent, selective, oral, small molecule inhibitor of ribonucleotide reductase (RNR). This is a first-in-human, open-label, non-randomized, 3-part, Phase 1/2 study to determine the safety profile and identify the maximum tolerated dose and recommended Phase 2 dose of BBI-825 administered as a single agent and in combination with select targeted therapies.

Clinical Trial Description

BBI-825 will be administered orally (PO) twice daily (BID) to subjects with locally advanced or metastatic non-resectable solid tumors, whose disease has progressed despite all standard therapies or for whom no further standard or clinically acceptable therapy exists. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06299761
Study type Interventional
Source Boundless Bio
Contact Sara Weymer
Phone 16198211090
Email ClinicalDevelopment@boundlessbio.com
Status Recruiting
Phase Phase 1
Start date March 28, 2024
Completion date February 2027
View Details
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