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Gentulizumab in Patients With Advanced Solid Malignancies and Non-Hodgkin Lymphoma

Solid Tumor Clinical Trial

Official title:
A Phase Ia, Open-label, Dose Escalation Study of Safety, Tolerability, Pharmacokinetics of Gentulizumab, an Anti-CD47 Monoclonal Antibody, in Patients With Advanced Solid Malignancies and Non-Hodgkin Lymphoma (NHL)

Clinical Trial Summary

The purpose of this study is to assess the safety and tolerability of gentulizumab, an anti-CD47 Monoclonal Antibody, in participants with solid tumors and non-Hodgkin lymphoma.

Clinical Trial Description

This is a first-in-human, escalating dose trial of an antibody that inhibits an anti-apoptotic signal in human macrophages. The major aims of the study are to define the safety profile of this new drug, and to determine a recommended dose and schedule for potential additional trials. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05221385
Study type Interventional
Source Changchun GeneScience Pharmaceutical Co., Ltd.
Contact
Status Terminated
Phase Phase 1
Start date April 12, 2021
Completion date October 27, 2023
View Details
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