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First-in-Human Study of ICT01 in Patients With Advanced Cancer — EVICTION  

Solid Tumor, Adult Clinical Trial

Official title:
A First-in-human, Two-part Clinical Study to Assess the Safety, Tolerability and Activity of IV Doses of ICT01 as Monotherapy and in Combination With a Checkpoint Inhibitor, in Patients With Advanced-stage, Relapsed/Refractory Cancer

Clinical Trial Summary

Part 1 will be a dose escalation study of IV ICT01 (a monoclonal antibody targeting BTN3A) as monotherapy in patients with advanced solid or hematologic tumors, followed by a cohort examining the combination of ICT01 plus pembrolizumab (Keytruda). Part 2 will be a cohort expansion into 2 solid tumor indications and one hematologic malignancy for ICT01 monotherapy, and 3 solid tumor indications for the combination of ICT01 plus pembrolizumab.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04243499
Study type Interventional
Source ImCheck Therapeutics
Contact Paul Frohna, MD, PhD
Phone 8582055285
Email paul.frohna@imcheck.fr
Status Recruiting
Phase Phase 1/Phase 2
Start date February 10, 2020
Completion date June 2024
View Details
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