Influenza Clinical Trial
Official title:
Efficacy and Safety of Influenza Vaccine in Cancer Patients Receiving Immune Checkpoint Inhibitor
The purpose of this study is to elucidate efficacy and safety of influenza vaccine in cancer patients receiving immune checkpoint inhibitor.
- Solid cancer patients receiving immune checkpoint inhibitor or cytotoxic chemotherapy
will be recruited 1:2 manner in two hospitals. Target numbers are 48 and 95,
respectively.
- All the participants will be vaccinated for influenza during their chemotherapy when
they meet inclusion criteria.
- All the participants will be asked if they have any contraindication for influenza
vaccine by a physician before vaccination.
- Hemagglutination inhibition Ab titre at pre-vaccination and post-vaccination (21-35 days
after vaccination) will be examined in all participants to examine seroprotection rates,
seroconversion rates, and changes in geometric mean titer.
- And they will be monitored for any vaccination-related adverse reaction or
immune-related adverse events after 2-4 days(via phone call), and till 6 months after
vaccination (when they visit oncology clinics).
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