Solid Cancers Clinical Trial
Official title:
A Phase 1b, Single-arm, Open-label Clinical Trial to Evaluate Corrected QT Interval and Drug-drug Interaction of Trastuzumab on Carboplatin in the Presence of Docetaxel in Patients With Metastatic Cancer
This Phase Ib, multicenter, single-arm, open-label study is designed to evaluate the effect
of trastuzumab on QTcF interval and to characterize the effects of trastuzumab on
carboplatin pharmacokinetics in patients with HER2-positive metastatic or locally advanced
inoperable cancer.
The QT interval is a measure of time between the start of the Q wave and the end of the T
wave in the heart's electrical cycle. The QTcF interval is the QT interval as calculated
using Fridericia's correction; the QTcB interval is the QT interval as calculated using
Bazett's correction.
n/a
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
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Phase 1 | |
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||
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Phase 1 |