Dietary Sodium, Oxidative Stress, and Pulsatile Hemodynamics

Sodium Excess Clinical Trial

Official title: The Role of Oxidative Stress and Endothelial Dysfunction in High Sodium-Induced Changes in Pulsatile Hemodynamics

Status Recruiting

Clinical Trial Summary

High sodium diets impair vascular function, which may influence the work of the heart. This investigation is designed to determine if this change in vascular function results in a greater workload in the heart and if people who regularly exercise are protected from these effects.

Clinical Trial Description

Excess dietary sodium is associated with cardiac hypertrophy independent of changes in blood pressure. Importantly, increased arterial pulsatile load predicts left ventricular hypertrophy, and thus presents a potential mechanism through which high dietary sodium augments cardiovascular disease risk.

While high sodium diets impair vascular function via an increase in oxidative stress, how high sodium influences central pulsatile hemodynamics is not known. This project aims to a) determine how impaired vascular function affects pulsatile hemodynamics and thus influences the work of the heart during periods of high sodium consumption and b) examine whether regular aerobic exercise and/or fitness protects against the deleterious effects of excess sodium. ;

Related Conditions & MeSH terms

• Hypernatremia
• Sodium Excess

• NCT number: NCT04233957
• Study type: Interventional
• Source: University of Delaware
• Contact: David G Edwards, PhD
• Phone: 302-831-3363
• Email: dge@udel.edu
• Status: Recruiting
• Phase: N/A
• Start date: January 1, 2020
• Completion date: December 31, 2024