Snoring Clinical Trial - Neostigmine For Snoring During DISE

Status Terminated

Clinical Trial Summary

The study team is seeking a novel treatment for snoring involving local application of a nerve stimulant medication, neostigmine. In this study, neostigmine will be injected into 5 sites of the soft palate during a standard procedure, drug-induced sleep endoscopy, to evaluate the effect on snoring.

Clinical Trial Description

Snoring is a major problem, affecting 40 million Americans. The disease affects patient and partner sleep quality as well as daytime function. Snoring treatment is limited by device compliance (mouth appliance, positive airway pressure) and insurance does not regularly pay for these devices. Surgical treatment for snoring has mixed results. As a result, there is an important need to develop new treatments for snoring.

The study team is seeking a novel treatment for snoring involving local application of a nerve stimulant medication, neostigmine. In this study, neostigmine will be injected into 5 sites of the soft palate during a standard procedure, drug-induced sleep endoscopy, to evaluate the effect on snoring. If successful, development of a topical (non-injectable) version of this drug will be considered, so that the patient can apply him/herself before bedtime. ;

Study Design

Related Conditions & MeSH terms

Snoring

Clinical Trial Details

NCT number	NCT03316963
Study type	Interventional
Source	Emory University
Contact
Status	Terminated
Phase	Early Phase 1
Start date	November 14, 2017
Completion date	March 19, 2019

View Details

See also
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