Smoking Clinical Trial
Official title:
Evaluation of the GCF Periostin, IL-17A and IL-17E Levels of Smoking and Non-smoking Periodontitis Patients Received Periodontal Treatment: Short-term Follow-up Study
Verified date | March 2024 |
Source | Ondokuz Mayis University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
It was aimed to evaluate the changes in the levels of Periostin, IL-17A and IL-17E cytokines in the gingival crevicular fluid (GCF) of periodontitis patients which non-surgical (Phase I) periodontal treatment applied to and their interactions with smoking. The study included systemic healthy smokers(SP)(n:11) and non-smokers(P)(n:11) with periodontitis, smokers (SS)(n:11) and non-smokers(S)(n:11) with periodontal healthy individuals Phase I periodontal treatment was applied to the groups with periodontitis. Before treatment (day 0), clinical measurements evaluating periodontal status were recorded and GCF samples were collected. GCF samples were collected from the same tooth regions on the 15th and 30th days after treatment and clinical measurements were repeated. GCF Periostin, IL-17A and IL-17E levels were determined by ELISA method. All data were evaluated statistically.
Status | Completed |
Enrollment | 44 |
Est. completion date | July 1, 2021 |
Est. primary completion date | February 1, 2021 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - generalized stage 3 periodontitis or periodontally healthy; - smoker ((=10 cigarettes/day for >5 years) or nonsmoker (never smoked in their lifetime); - not have received any periodontal treatment in the last 6 months, took any antibiotics, anti-inflammatory drugs regularly and for female subjects, not to be pregnant, lactating, or menopause. Exclusion Criteria: - Under 18 years of age - Those with a systemic disease - Cancer patients, those with a history of chemotherapy and radiotherapy - Pregnant and breastfeeding women - Those who smoke less than 10 cigarettes a day and those who quit smoking - Having received orthodontic treatment in the last 6 months - Using antibiotics, anti-inflammatory or any medication in the last 6 months - Those who do not consent voluntarily |
Country | Name | City | State |
---|---|---|---|
Turkey | Ondokuz Mayis University Faculty of Dentistry Department of Periodontology | Samsun |
Lead Sponsor | Collaborator |
---|---|
Ondokuz Mayis University |
Turkey,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Evaluation of Periostin levels | The effect of non-surgical periodontal treatment in gingival crevicular fluid periostin levels | 0-15-30 days | |
Primary | Evaluation of IL-17A levels | The effect of non-surgical periodontal treatment in gingival crevicular fluid IL-17A levels | 0-15-30 days | |
Primary | Evaluation of IL-17E levels | The effect of non-surgical periodontal treatment in gingival crevicular fluid IL-17E levels | 0-15-30 days | |
Secondary | Interaction Between Smoking and GCF Periostin, IL17A, IL17E levels | Comparisons between groups were made to evaluate the effect of smoking on non-surgical periodontal treatment. | 0-15-30 days |
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