Smoking Clinical Trial - Metabolism of NNK in Japanese Americans

Status Recruiting

Clinical Trial Summary

The risk of lung cancer varies by individual and by ethnic/racial group. In this study the investigators will explore how individual differences in the metabolism of a tobacco-specific lung carcinogen may contribute to the variable risk of lung cancer between ethnic/racial groups. In this 10 day clinical trial, Japanese Americans will smoke a cigarette containing deuterium-labeled 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific lung carcinogen. The study cigarette will be smoked for 7 days. This will allow for NNK metabolic profiling and determining the effect of CYP2A6 genotype on the level of NNK α-hydroxylation in Japanese Americans smokers using [pyridine- D4]-NNK containing cigarettes.

Clinical Trial Description

Eligible subjects will provide a baseline 24 hour urine sample. Study cigarettes spiked with labeled NNK will be provided to the subjects to smoke over a 7 day period. During this time, 24 hour urine samples will be collected over days 5, 6 and 7 on study cigarettes. Blood will be drawn on days 6 and 7 on study cigarettes. Samples will be analyzed for NNK metabolism. ;

Study Design

Related Conditions & MeSH terms

Smoking

Clinical Trial Details

NCT number	NCT04228952
Study type	Observational
Source	Masonic Cancer Center, University of Minnesota
Contact	Joni Jensen, MPH
Phone	612-624-5178
Email	jense010@umn.edu
Status	Recruiting
Phase
Start date	September 1, 2020
Completion date	December 31, 2024

View Details

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