Smoking Clinical Trial
Official title:
The Effect of Synbiotic Tablet Usage on the Clinical and Biochemical Parameters in Smokers and Nonsmokers With Gingivitis: A Randomized Placebo-Controlled Clinical Trial
The aim of this study is to evaluate the efficacy of oral administration of synbiotic tablets
on the clinical parameters and the levels of selected inflammatory mediators in gingival
crevicular fluid (GCF) in smokers and non-smokers with gingivitis.
This study designed as a double-blind randomized placebo-controlled clinical trial.
Some patients like smokers have ongoing host response even after bacterial plaque removal
achieved. Therefore efforts to develop effective treatment approaches remain an important
objective in the treatment of gingivitis to prevent periodontitis especially in patients at
high risk for developing periodontitis as smokers.
Smoking is a major risk factor for the incidence and the progression of periodontal diseases.
The increased periodontal disease susceptibility in smokers is predominantly caused by
changes in inflammatory and immune responses. Cigarette smoking also influences the amount
and the composition of subgingival plaque. Smokers have higher numbers of pathogens in their
resident biofilm and display an ongoing host response even after biofilm removal. Different
approaches were explored to reduce the negative effects of smoking on the outcomes of
periodontal therapy Synbiotic were defined as a mixture of probiotics and prebiotics that
beneficially affects the host by improving the survival and implantation of live microbial
dietary supplements in the gastrointestinal tract, by selectively stimulating the growth
and/or by activating the metabolism of one or a limited number of health-promoting bacteria,
and thus improving host welfare. Also in some cases, this may lead to a competitive advantage
for the probiotics among with other bacteria.
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