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Effect of Smoking on the Expression of Gelatinases in Chronic Periodontitis

Smoking Clinical Trial

Official title:
The Effect of Smoking on the Expression of Gelatinases in Chronic Periodontitis: A Cross-sectional Study

Clinical Trial Summary

This study comparatively evaluate the expressions of MMP-2 and MMP-9 in smoker vs non-smoker chronic periodontitis patients as well as periodontally healthy subjects. the hypothesis of this study was that smoking may interfere with periodontal disease by effecting MMP-2 and MMP-9 expressions.

Clinical Trial Description

Smokers have greater risk for developing periodontal disease and smoking is highly correlated with greater marginal bone loss. Matrix metalloproteinases (MMP) play a major role in periodontal tissue destruction. MMP-2 and MMP-9, called gelatinases, are one of the major MMPs that plays important roles in periodontitis. To date, several studies showed the increased levels of gelatinases in periodontal disease and only a limited number of study investigated the effect of smoking on gelatinases. However, no previous study has directly investigated the possible relationship between smoking and gingival tissue gelatinases expressions (MMP-2 and MMP-9) in chronic periodontitis (CP) patients relative to periodontally healthy subjects.

Therefore this study is conducted to comparatively evaluate the expressions of MMP-2 and MMP-9 in smoker vs non-smoker chronic periodontitis patients as well as periodontally healthy subjects. the of this study hypothesis was that smoking may interfere with periodontal disease by effecting MMP-2 and MMP-9 expressions. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03426241
Study type Observational
Source Baskent University
Contact
Status Completed
Phase N/A
Start date February 10, 2010
Completion date December 30, 2012
View Details
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