Smoking Clinical Trial
— TCAOfficial title:
Response-to-injury in Patients Undergoing Transradial Coronary Angiography: Arterial Remodeling in Smokers
Verified date | June 2014 |
Source | Heinrich-Heine University, Duesseldorf |
Contact | n/a |
Is FDA regulated | No |
Health authority | Germany: Ethics Commission |
Study type | Observational |
Cigarette smoking is the most important modifiable cardiovascular risk factor leading to endothelial dysfunction and was suggested to impair arterial regeneration.The aim of the study was to investigate the effect of smoking on vascular response to transradial coronary angiography (TCA).
Status | Completed |
Enrollment | 50 |
Est. completion date | June 2014 |
Est. primary completion date | June 2014 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 18 Years to 85 Years |
Eligibility |
Inclusion Criteria: - all subjects underwent a TCA Exclusion Criteria: - acute inflammation cardiac arrhythmia renal failure heart failure (NYHA II-IV) CRP > 1 mg/dl malignant disease |
Observational Model: Case Control, Time Perspective: Cross-Sectional
Country | Name | City | State |
---|---|---|---|
Germany | Division of Cardiology, Pulmonology and Vascular Medicine Duesseldorf, | Duesseldorf | NRW |
Lead Sponsor | Collaborator |
---|---|
Klinik für Kardiologie, Pneumologie und Angiologie |
Germany,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | cell migration | measured by boyden chamber from blood plasma | baseline | No |
Other | Regeneration | measured by scratch assay | baseline | No |
Primary | IMT hyperplasia | IMT is measured by high resolution ultrasound in the radial arteries. | change in radials IMT after 6-14 month after a TCA | No |
Secondary | Endothelial function | Flow mediated dilatation (FMD) | change in flow mediated dilatation after 10-14 months | No |
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